ArticleNaunyn-Schmiedeberg's archives of pharmacology1993
Relationship between myoglobin contents and increases in cyclic GMP produced by glyceryl trinitrate and nitric oxide in rabbit aorta, right atrium and papillary muscle.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Nitric oxide effects depend on different mechanisms in different regions of the rat heart.Heart and vessels · 2012Article
- Hemoglobin: a nitric-oxide dioxygenase.Scientifica · 2012Review
- Nitrite as regulator of hypoxic signaling in mammalian physiology.Medicinal research reviews · 2009Review
- Heme proteins mediate the conversion of nitrite to nitric oxide in the vascular wall.American journal of physiology. Heart and circulatory physiology · 2008Article
- Effects of nitric oxide donors on cardiac contractility in wild-type and myoglobin-deficient mice.British journal of pharmacology · 2002Article
- Inotropic response to beta-adrenergic receptor stimulation and anti-adrenergic effect of ACh in endothelial NO synthase-deficient mouse hearts.The Journal of physiology · 2001Article
- G protein-mediated inhibitory effect of a nitric oxide donor on the L-type Ca2+ current in rat ventricular myocytes.The Journal of physiology · 2001Article
- Inhibition of nitric oxide synthase augments the positive inotropic effect of nitric oxide donors in the rat heart.The Journal of physiology · 2000Article
- Peroxynitrite is a positive inotropic agent in atrial and ventricular fibres of the frog heart.The Journal of physiology · 1999Article
- Positive and negative inotropic effects of NO donors in atrial and ventricular fibres of the frog heart.The Journal of physiology · 1999Article
- Failure of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) to inhibit soluble guanylyl cyclase in rat ventricular cardiomyocytes.British journal of pharmacology · 1999Article
- Activation of distinct cAMP-dependent and cGMP-dependent pathways by nitric oxide in cardiac myocytes.Circulation research · 1999Article
- Negative inotropic actions of nitric oxide require high doses in rat cardiac muscle.Pflugers Archiv : European journal of physiology · 1996Article
- Regulation of myocardial calcium channels by cyclic AMP metabolism.Basic research in cardiology · 1996Review
- The ineffectiveness of the NO-cyclic GMP signaling pathway in the atrial myocardium.British journal of pharmacology · 1995Article
- Nitric oxide regulates the calcium current in isolated human atrial myocytes.The Journal of clinical investigation · 1995Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Effects of glyceryl trinitrate (GTN) and nitric oxide (NO) on the cardiac functions and myocardial cyclic GMP (cGMP) contents were examined in comparison with those in the aorta and correlated with myoglobin (an inhibitor of soluble guanylate cyclase) contents using the preparations isolated from the reserpinized rabbit. GTN (10(-10)-10(-4) mol/l) produced a dose-dependent relaxation in the aorta. However, this compound exerted no effect on the rate of the spontaneous beat of the right atrium and the contraction of the papillary muscle. A transient and significant increase in cGMP was observed in the aorta with GTN (3 x 10(-6) mol/l). Although the increase was also observed in the right atrium, it was much smaller. No definite change was observed in papillary muscle. Increases in cGMP produced by NO (3 x 10(-6) mol/l) were larger and significant in all tissues; (AUCcGMP(GTN)/AUCcGMP(NO)) ratio was 30.1 for the aorta, 65.0 for the right atrium and 16.3% for the papillary muscle. Although higher concentrations of NO were necessary in the right atrium and papillary muscle to induce increases in cGMP, no differences were noted in the three tissues as regards the maximum accumulation of this substance. Furthermore, kinetic analysis of NO-induced increases in tissue cGMP indicated no marked difference in the production rate among the three tissues, while the rate of elimination of cGMP was lower in the aorta than in the atrium or the papillary muscle. The increases in cGMP observed in these three tissues were inversely related to the contents of myoglobin in respective tissues.(ABSTRACT TRUNCATED AT 250 WORDS)
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.