ReviewMolecular neurobiology1993
Novel oligodendrocyte transmembrane signaling systems. Investigations utilizing antibodies as ligands.
Review in Molecular neurobiology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 71 citations in OpenAlex.
- Evaluation of locomotor function and microscopic structure of the spinal cord in a mouse model of experimental autoimmune encephalomyelitis following treatment with syngeneic mesenchymal stem cells.International journal of clinical and experimental pathology · 2015Article
- Autoimmune T-cell reactivity to myelin proteolipids and glycolipids in multiple sclerosis.Multiple sclerosis international · 2013Review
- Remyelination-promoting human IgMs: developing a therapeutic reagent for demyelinating disease.Current topics in microbiology and immunology · 2008Review
- Transcriptional regulation of the human UDP-galactose:ceramide galactosyltransferase (hCGT) gene expression: functional role of GC-box and CRE.Glycoconjugate journal · 2004Article
- A glycosynapse in myelin?Glycoconjugate journal · 2004Review
- The structure and function of myelin: from inert membrane to perfusion pump.Neurochemical research · 2002Review
- Myelin-associated glycoprotein and myelin galactolipids stabilize developing axo-glial interactions.The Journal of cell biology · 2002Article
- Negative regulation of oligodendrocyte differentiation by galactosphingolipids.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Insertion of a retrotransposon in Mbp disrupts mRNA splicing and myelination in a new mutant rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Tenascin-R is an intrinsic autocrine factor for oligodendrocyte differentiation and promotes cell adhesion by a sulfatide-mediated mechanism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Functional breakdown of the lipid bilayer of the myelin membrane in central and peripheral nervous system by disrupted galactocerebroside synthesis.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Developmental expression of MOSP in cultured oligodendrocytes.Neurochemical research · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Antibodies are increasingly being used as tools to study the function of cell surface markers. Several types of responses may occur upon the selective binding of an antibody to an epitope on a receptor. Antibody binding may trigger signals that are normally transduced by endogenous ligands. Moreover, antibody binding may activate normal signals in a manner that disrupts a sequence of events that coordinates either differentiation, mitogenesis, or morphogenesis. Alternately, it is possible that binding elicits either a modified signal or no signal. This article focuses on the cascade of events that occur following specific antibody binding to myelin markers expressed by cultured murine oligodendrocytes. Binding of specific antibodies to the oligodendrocyte membrane surface markers myelin/oligodendrocyte glycoprotein (MOG), myelin/oligodendrocyte specific protein (MOSP), galactocerebroside (GalC), and sulfatide on cultured murine oligodendrocytes results in different effects with regard to phospholipid turnover, Ca2+ influxes, and antibody:marker distribution. The consequence of each antibody-elicited cascade of events appears to be the regulation of the cytoskeleton within the oligodendroglial membrane sheets. The antibody binding studies described in this article demonstrate that these myelin surface markers are capable of transducing signals. Since endogenous ligands for these myelin markers have yet to be identified, it is not known if these signals are normally transduced or are a modification of normally transduced signals.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.