ArticleThe American journal of pathology1993
Nuclear A-type lamins are differentially expressed in human lung cancer subtypes.
Article in The American journal of pathology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
What it found
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Who cites it
71 citing papers in PubMed, 141 citations in OpenAlex.
- Lamin subtype expression in Merkel-cell carcinoma: its relation to polyomavirus infection and tumor metastasis.Histochemistry and cell biology · 2026Article
- Lamin A/C as a Molecular Link Between Nuclear Organization, Chromatin Dynamics, and Tumor Progression.Cells · 2026Review
- Variable A-type lamin expression in Merkel cell carcinoma cell lines and its association with nuclear integrity.Scientific reports · 2026Article
- Divergent Contribution of Cytoplasmic Actins to Nuclear Structure of Lung Cancer Cells.International journal of molecular sciences · 2024Article
- Insulin Receptor Isoforms and Insulin Growth Factor-like Receptors: Implications in Cell Signaling, Carcinogenesis, and Chemoresistance.International journal of molecular sciences · 2023Review
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- A-type lamins involvement in transport and implications in cancer?Nucleus (Austin, Tex.) · 2022Review
- Constricted migration is associated with stable 3D genome structure differences in cancer cells.EMBO reports · 2022Article
- Lamin-A/C Is Modulated by the Involvement of Histamine-Mediated Calcium/Calmodulin-Dependent Kinase II in Lung Cancer Cells.International journal of molecular sciences · 2022Article
- Lamin B1 deletion in myeloid neoplasms causes nuclear anomaly and altered hematopoietic stem cell function.Cell stem cell · 2022Article
- Multilevel view on chromatin architecture alterations in cancer.Frontiers in genetics · 2022Review
- Nuclear Morphological Abnormalities in Cancer: A Search for Unifying Mechanisms.Results and problems in cell differentiation · 2022Article
- Article
- Role of Lamin A and emerin in maintaining nuclear morphology in different subtypes of ovarian epithelial cancer.Oncology letters · 2022Article
- The Role of Emerin in Cancer Progression and Metastasis.International journal of molecular sciences · 2021Review
- Reduced Lamin A/C Does Not Facilitate Cancer Cell Transendothelial Migration but Compromises Lung Metastasis.Cancers · 2021Article
- 3-Dimensional organization and dynamics of the microsporidian polar tube invasion machinery.PLoS pathogens · 2020Article
- Review
- Review
- Nesprin-1 impact on tumorigenic cell phenotypes.Molecular biology reports · 2020Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear A-type and B-type lamin expression was investigated in the major human lung cancer subtypes: small cell lung cancer (SCLC), squamous cell carcinomas, and adenocarcinomas (both non-SCLC). Twenty-two human lung cancer cell lines and 46 fresh frozen human lung cancer specimens were examined. Expression of B-type lamins was found in all the different cell lines. A-type lamins were expressed in all non-SCLC cell lines but were absent or only weakly expressed in 14 out of 16 SCLC cell lines. The immunocytochemical results were confirmed by immunoblotting and Northern blot analyses. In sections of SCLCs and non-SCLCs, B-type lamins were found to be expressed in all tumors. However, in some non-SCLCs, particularly in adenocarcinomas, a considerable proportion of the tumor cells were negative for B-type lamins. A-type lamin expression in SCLCs was weakly positive or negative in 14 out of 15 cases. In contrast, all non-SCLCs displayed A-type lamins, but in several of these samples, both cytoplasmic and nuclear staining was observed.
Indexed as
Identifiers
8391215PMC1886958W1553065669What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.