Evidence map›Paper›PMID 8390674›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America1993

Identification of a human achaete-scute homolog highly expressed in neuroendocrine tumors.

D W Ball, C G Azzoli, S B Baylin, D Chi, S Dou, H Donis-Keller, A Cumaraswamy, M Borges, B D Nelkin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 180 citations in OpenAlex.

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  8. Distinct transcriptional programs of SOX2 in different types of small cell lung cancers.Laboratory investigation; a journal of technical methods and pathology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

D W BallDivision of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
C G Azzoli
S B Baylin
D Chi
S Dou
H Donis-Keller
A Cumaraswamy
M Borges
B D Nelkin
Johns Hopkins University · US

Funding

DIFFERENTIATION OF MEDULLARY THYROID CARCINOMA CELLSR01CA047480 · NCI · JOHNS HOPKINS UNIVERSITY · PI NELKIN, BARRY D. · 1988 to 2000
$398k
PROGRAM PHYSICIAN SCIENTIST AWARDK12DK001298 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI STOBO, JOHN D · 1986 to 1997
–
NCI NIH HHS R01 CA47480NCI NIH HHS R01 CA53524NIDDK NIH HHS K12-DK01298
6 · The paper itself

Abstract

Basic helix-loop-helix transcription factors of the achaete-scute family are instrumental in Drosophila neurosensory development and are candidate regulators of development in the mammalian central nervous system and neural crest. We report the isolation and initial characterization of a human achaete-scute homolog that is highly expressed in two neuroendocrine cancers, medullary thyroid cancer (MTC) and small cell lung cancer (SCLC). The human gene, which we have termed human achaete-scute homology 1 (hASH1), was cloned from a human MTC cDNA library. It encodes a predicted protein of 238 aa that is 95% homologous to mammalian achaete-scute homolog (MASH) 1, a rodent basic helix-loop-helix factor. The 57-residue basic helix-loop-helix domain is identical to that in the rodent gene, and the basic and helical regions, excluding the loop, are 72-80% identical to Drosophila achaete-scute family members. The proximal coding region of the hASH1 cDNA contains a striking 14-copy repeat of the triplet CAG that exhibits polymorphism in human genomic DNA. Thus, hASH1 is a candidate locus for disease-causing mutations via triplet repeat amplification. Analysis of rodent-human somatic cell hybrids permitted assignment of hASH1 to human chromosome 12. Northern blots revealed hASH1 transcripts in RNA from a human MTC cell line, two fresh MTC tumors, fetal brain, and three lines of human SCLC. In contrast, cultured lines of non-SCLC lung cancers and a panel of normal adult human tissues showed no detectable hASH1 transcripts. Expression of hASH1 may provide a useful marker for cancers with neuroendocrine features and may contribute to the differentiation and growth regulation of these cells.

Indexed as

Polymorphism, GeneticRepetitive Sequences, Nucleic AcidAdrenal Gland NeoplasmsAdultAmino Acid SequenceAnimalsBase SequenceBrainCarcinoma, Small CellCell LineChromosome MappingDNADNA, NeoplasmDrosophilaFetusHumansDNADNA, NeoplasmOligodeoxyribonucleotidesTranscription Factors

Identifiers

PMID8390674
PMCPMC46778
OpenAlexW2027459193

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.