ArticleMolecular & general genetics : MGG1993
Growth-related expression of ribosomal protein genes in Saccharomyces cerevisiae.
Article in Molecular & general genetics : MGG, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 73 citations in OpenAlex.
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- Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae.FEMS microbiology reviews · 2014Review
- Yeast phospholipase C is required for normal acetyl-CoA homeostasis and global histone acetylation.The Journal of biological chemistry · 2013Article
- Life in the midst of scarcity: adaptations to nutrient availability in Saccharomyces cerevisiae.Current genetics · 2010Review
- Pathway analysis for intracellular Porphyromonas gingivalis using a strain ATCC 33277 specific database.BMC microbiology · 2009Article
- Global transcriptional response of Saccharomyces cerevisiae to the deletion of SDH3.BMC systems biology · 2009Article
- Transcription factor control of growth rate dependent genes in Saccharomyces cerevisiae: a three factor design.BMC genomics · 2008Article
- Global responses of Methanococcus maripaludis to specific nutrient limitations and growth rate.Journal of bacteriology · 2008Article
- The gene expression data of Mycobacterium tuberculosis based on Affymetrix gene chips provide insight into regulatory and hypothetical genes.BMC microbiology · 2007Article
- Growth control of the eukaryote cell: a systems biology study in yeast.Journal of biology · 2007Article
- The yeast CPC2/ASC1 gene is regulated by the transcription factors Fhl1p and Ifh1p.Current genetics · 2006Article
- Osmotic stress signaling and osmoadaptation in yeasts.Microbiology and molecular biology reviews : MMBR · 2002Review
- Transcript analysis of 1003 novel yeast genes using high-throughput northern hybridizations.The EMBO journal · 2001Article
- Understanding the growth phenotype of the yeast gcr1 mutant in terms of global genomic expression patterns.Journal of bacteriology · 2000Article
- Complex regulation of the yeast heat shock transcription factor.Molecular biology of the cell · 2000Article
- In vivo analysis of functional regions within yeast Rap1p.Molecular and cellular biology · 1999Article
- Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae.Molecular biology of the cell · 1999Article
- A role for RNA metabolism in inducing the heat shock response.Gene expression · 1999Article
- Cluster analysis and display of genome-wide expression patterns.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rate of ribosomal protein gene (rp-gene) transcription in yeast is accurately adjusted to the cellular requirement for ribosomes under various growth conditions. However, the molecular mechanisms underlying this co-ordinated transcriptional control have not yet been elucidated. Transcriptional activation of rp-genes is mediated through two different multifunctional transacting factors, ABF1 and RAP1. In this report, we demonstrate that changes in cellular rp-mRNA levels during varying growth conditions are not parallelled by changes in the in vitro binding capacity of ABF1 or RAP1 for their cognate sequences. In addition, the nutritional upshift response of rp-genes observed after addition of glucose to a culture growing on a non-fermentative carbon source turns out not to be the result of increased expression of the ABF1 and RAP1 genes or of elevated DNA-binding activity of these factors. Therefore, growth rate-dependent transcription regulation of rp-genes is most probably not mediated by changes in the efficiency of binding of ABF1 and RAP1 to the upstream activation sites of these genes, but rather through other alterations in the efficiency of transcription activation. Furthermore, we tested the possibility that cAMP may play a role in elevating rp-gene expression during a nutritional shift-up. We found that the nutritional upshift response occurs normally in several mutants defective in cAMP metabolism.
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