ArticleThe American journal of pathology1993
Reduced nm 23-H1 messenger RNA expression in metastatic lymph nodes from patients with papillary carcinoma of the thyroid.
Article in The American journal of pathology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 34 citations in OpenAlex.
- NDPKA is not just a metastasis suppressor - be aware of its metastasis-promoting role in neuroblastoma.Laboratory investigation; a journal of technical methods and pathology · 2018Article
- NME2 reduces proliferation, migration and invasion of gastric cancer cells to limit metastasis.PloS one · 2015Article
- Metastatic mechanisms in follicular cell-derived thyroid cancer.Endocrine-related cancer · 2013Review
- Metastatic dormancy and progression in thyroid cancer: targeting cells in the metastatic frontier.Thyroid : official journal of the American Thyroid Association · 2011Review
- Molecular biology of breast cancer metastasis. Genetic regulation of human breast carcinoma metastasis.Breast cancer research : BCR · 2000Review
- Potential prognostic value in human breast cancer of cytosolic Nme1 protein detection using an original hen specific antibody.British journal of cancer · 1996Article
- Article
- Expression of nm23-H1 gene product in thyroid, ovary, and breast cancers.Cell biophysics · 1995Article
- Immunohistochemical detection of nm23/NDP kinase and cathepsin D in medullary carcinomas of the thyroid gland.Virchows Archiv : an international journal of pathology · 1995Article
- Immunohistochemical analysis of nm23 protein expression in malignant bone tumors.Journal of cancer research and clinical oncology · 1995Article
- NM23 protein in neoplastic and nonneoplastic thyroid tissues.The American journal of pathology · 1994Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nm 23 gene product, which possesses nucleoside diphosphate kinase activity, is a possible mediator of cancer cell invasion and metastasis. It has been divided into two distinct gene products, nm23-H1 and nm23-H2. We have developed a method for detecting nm 23-H1 and nm 23-H2 RNA using the polymerase chain reaction, based on the amplification of complementary DNA copies of nm 23-H1 and nm 23-H2 RNA. Using this method, the nm 23-H1 and nm 23-H2 messenger (m)RNA levels in 35 thyroid papillary carcinomas, 11 metastatic lymph nodes from patients with thyroid papillary carcinomas, five thyroid follicular adenomas, and three normal thyroid tissue samples were studied. Both nm 23-H1 and nm 23-H2 mRNA were expressed ubiquitously in normal and malignant thyroid tissues. However, in metastatic lymph nodes no (3 of 11) or weak expression (8 of 11) of nm 23-H1 mRNA was observed, the extent of which was inversely proportional to the degree of cancer cell occupancy, whereas nm 23-H2 mRNA was expressed and the levels were similar to those in other tissue tested. These results show that nm 23-H1 only may play a role in cancer cell invasion and metastasis although the exact mechanisms involved have yet to be elucidated.
Indexed as
Identifiers
8389529PMC1886999W15358203What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.