ArticleProceedings of the National Academy of Sciences of the United States of America1993
Analysis of the mouse protamine 1 promoter in transgenic mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 110 citations in OpenAlex.
- Critical Role of Rho Guanine Nucleotide Exchange Factor 4 in Brain Function.Molecular neurobiology · 2025Article
- Overexpression of PD-L1 causes germ cells to slough from mouse seminiferous tubules via the PD-L1/PD-L1 interaction.Journal of cellular and molecular medicine · 2022Article
- Offspring production of haploid spermatid-like cells derived from mouse female germline stem cells with chromatin condensation.Cell & bioscience · 2022Article
- Evolution of a New Testis-Specific Functional Promoter Within the Highly ConservedFrontiers in genetics · 2021Article
- A 50-bp enhancer of the mouse acrosomal vesicle protein 1 gene activates round spermatid-specific transcription in vivo†.Biology of reproduction · 2019Article
- DDX4-EGFP transgenic rat model for the study of germline development and spermatogenesis.Biology of reproduction · 2017Article
- PiggyBac transposon-based polyadenylation-signal trap for genome-wide mutagenesis in mice.Scientific reports · 2016Article
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- A Mammalian enhancer trap resource for discovering and manipulating neuronal cell types.eLife · 2016Article
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- Aromatase-null mice expressing enhanced green fluorescent protein in germ cells provide a model system to assess estrogen-dependent ovulatory responses.Transgenic research · 2014Article
- Three levels of regulation lead to protamine and Mst77F expression in Drosophila.Developmental biology · 2013Article
- Identification and characterization of promoter and regulatory regions for mouse Adam2 gene expression.Molecular biology reports · 2013Article
- The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.PloS one · 2013Article
- Increased expression of the Na,K-ATPase alpha4 isoform enhances sperm motility in transgenic mice.Biology of reproduction · 2011Article
- Functional cooperation between CREM and GCNF directs gene expression in haploid male germ cells.Nucleic acids research · 2010Article
- Seminiferous tubule transfection in vitro to define post-meiotic gene regulation.Reproductive biology and endocrinology : RB&E · 2009Article
- Identification and characterization of a novel testis-specific gene CKT2, which encodes a substrate for protein kinase CK2.Nucleic acids research · 2009Article
- Characterization of a Dazl-GFP germ cell-specific reporter.Genesis (New York, N.Y. : 2000) · 2009Article
- Impaired fertility and spermiogenetic disorders with loss of cell adhesion in male mice expressing an interfering Rap1 mutant.Molecular biology of the cell · 2007Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Protamines are small arginine-rich proteins that package DNA in spermatozoa. The mouse protamine 1 (Prm-1) gene is transcribed exclusively in post-meiotic spermatids. To identify elements in the Prm-1 promoter required for spermatid-specific transcription, we generated transgenic mice by microinjection of transgenes containing Prm-1 5' flanking sequences with 5' truncations or internal deletions of conserved sequences linked to a marked Prm-1 gene. We also tested Prm-1 promoter regions with a heterologous human growth hormone reporter gene. We conclude that a 113-bp region can direct spermatid-specific transcription and we have defined sequences within this region that are essential for proper function. These results will facilitate the isolation and characterization of transcription factors essential for post-meiotic gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.