ArticleMolecular and cellular biology1993
The cardiac troponin T alternative exon contains a novel purine-rich positive splicing element.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.
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Who cites it
106 citing papers in PubMed.
- Early Divergence of the C-Terminal Variable Region of Troponin T Via a Pair of Mutually Exclusive Alternatively Spliced Exons Followed by a Selective Fixation in Vertebrate Heart.Journal of molecular evolution · 2022Article
- Alternative Pre-mRNA Splicing of the Mu Opioid Receptor Gene,Biomolecules · 2021Review
- A Depletion of Stop Codons in lincRNA is Owing to Transfer of Selective Constraint from Coding Sequences.Molecular biology and evolution · 2020Article
- Ranking noncanonical 5' splice site usage by genome-wide RNA-seq analysis and splicing reporter assays.Genome research · 2018Article
- Evidence that a threshold of serine/arginine-rich (SR) proteins recruits CFIm to promote rous sarcoma virus mRNA 3' end formation.Virology · 2016Article
- The evolution, impact and properties of exonic splice enhancers.Genome biology · 2013Article
- Genomic features defining exonic variants that modulate splicing.Genome biology · 2010Article
- Article
- Multisite and bidirectional exonic splicing enhancer in CD44 alternative exon v3.RNA (New York, N.Y.) · 2007Article
- Interplay between exonic splicing enhancers, mRNA processing, and mRNA surveillance in the dystrophic Mdx mouse.PloS one · 2007Article
- Therapeutic potential and mechanism of kinetin as a treatment for the human splicing disease familial dysautonomia.Journal of molecular medicine (Berlin, Germany) · 2007Article
- A bichromatic fluorescent reporter for cell-based screens of alternative splicing.Nucleic acids research · 2006Article
- Dichotomous splicing signals in exon flanks.Genome research · 2005Article
- Hrp59, an hnRNP M protein in Chironomus and Drosophila, binds to exonic splicing enhancers and is required for expression of a subset of mRNAs.The Journal of cell biology · 2005Article
- Exonic splicing enhancers in fission yeast: functional conservation demonstrates an early evolutionary origin.Genes & development · 2005Article
- Muscleblind proteins regulate alternative splicing.The EMBO journal · 2004Article
- An intronic enhancer regulates splicing of the twintron of Drosophila melanogaster prospero pre-mRNA by two different spliceosomes.Molecular and cellular biology · 2004Article
- B-cell and plasma-cell splicing differences: a potential role in regulated immunoglobulin RNA processing.RNA (New York, N.Y.) · 2003Article
- Alternative splicing of U12-dependent introns in vivo responds to purine-rich enhancers.RNA (New York, N.Y.) · 2001Article
- Functionally antagonistic sequences are required for normal autoregulation of Drosophila tra-2 pre-mRNA splicing.Nucleic acids research · 2001Article
46 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have characterized a novel positive-acting splicing element within the developmentally regulated alternative exon (exon 5) of the cardiac troponin T (cTNT) gene. The exon splicing element (ESE) is internal to the exon portions of the splice sites and is required for splicing to the 3' splice site but not the 5' splice site flanking the exon. Sequence comparisons between cTNT exon 5 and other exons that contain regions required for splicing reveal a common purine-rich motif. Sequence within cTNT exon 5 or a synthetic purine-rich motif facilitates splicing of heterologous alternative and constitutive splice sites in vivo. Interestingly, the ESE is not required for the preferential inclusion of cTNT exon 5 observed in primary skeletal muscle cultures. Our results strongly suggest that the purine-rich ESE serves as a general splicing element that is recognized by the constitutive splicing machinery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.