ArticleBiophysical journal1993
Procaine effects on single sarcoplasmic reticulum Ca2+ release channels.
Article in Biophysical journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 56 citations in OpenAlex.
- ProcClusterFrontiers in microbiology · 2024Article
- Novel Strategies to Improve the Cardioprotective Effects of Cardioplegia.Current cardiology reviews · 2024Review
- CaHeart rhythm · 2018Review
- Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation.Heart rhythm · 2008Article
- Differential effects of voltage-dependent inactivation and local anesthetics on kinetic phases of Ca2+ release in frog skeletal muscle.Biophysical journal · 2003Article
- Sarcoplasmic reticulum calcium load regulates rat arterial smooth muscle calcium sparks and transient K(Ca) currents.The Journal of physiology · 2002Article
- A model of the L-type Ca2+ channel in rat ventricular myocytes: ion selectivity and inactivation mechanisms.The Journal of physiology · 2000Article
- Modulation of CICR has no maintained effect on systolic Ca2+: simultaneous measurements of sarcoplasmic reticulum and sarcolemmal Ca2+ fluxes in rat ventricular myocytes.The Journal of physiology · 2000Article
- Regulation of the cardiac ryanodine receptor channel by luminal Ca2+ involves luminal Ca2+ sensing sites.Biophysical journal · 1998Article
- The effect of tetracaine on stimulated contractions, sarcoplasmic reticulum Ca2+ content and membrane current in isolated rat ventricular myocytes.The Journal of physiology · 1998Article
- The effect of tetracaine on spontaneous Ca2+ release and sarcoplasmic reticulum calcium content in rat ventricular myocytes.The Journal of physiology · 1997Article
- Dual effects of tetracaine on spontaneous calcium release in rat ventricular myocytes.The Journal of physiology · 1997Article
- A minimal gating model for the cardiac calcium release channel.Biophysical journal · 1996Article
- Characteristics of cocaine block of purified cardiac sarcoplasmic reticulum calcium release channels.Biophysical journal · 1996Article
- Description of modal gating of the cardiac calcium release channel in planar lipid membranes.Biophysical journal · 1995Article
- Cytoplasmic Ca2+ inhibits the ryanodine receptor from cardiac muscle.The Journal of membrane biology · 1995Article
- Suppression of calcium release by calcium or procaine in voltage clamped rat skeletal muscle fibres.The Journal of physiology · 1995Article
- Measuring the length of the pore of the sheep cardiac sarcoplasmic reticulum calcium-release channel using related trimethylammonium ions as molecular calipers.Biophysical journal · 1995Article
- Modification of cardiac Ca2+ release channel gating by DIDS.Pflugers Archiv : European journal of physiology · 1993Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The effects of the Ca(2+)-induced Ca2+ release blocker procaine on individual sarcoplasmic reticulum Ca2+ release channels have been examined in planar lipid bilayers. Procaine did not reduce the single channel conductance nor appreciably shorten the mean open times of the channel; rather, it increased the longest closed time. These results indicated that procaine interacted selectively with a closed state of the channel rather than with an open state. Gating of the sarcoplasmic reticulum Ca2+ release channel was described by a modified scheme of Ashley and Williams (1990. J. Gen. Physiol. 95:981-1005), including an additional long-lived closed state. Computer simulations determined that procaine was more likely to interact with this long-lived Ca(2+)-bound closed state of the channel rather than with other states of the channel. Simulations with the same model were also able to reproduce a prominent Ca(2+)-sensitive transition between "random" and "bursting" forms of gating of the channel, variations of which may account for "gearshift" behavior reported in studies with this and other single channels.
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