ArticleThe American journal of pathology1993
Altered integrin expression in adenocarcinoma of the breast. Analysis by in situ hybridization.
Article in The American journal of pathology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 98 citations in OpenAlex.
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- Article
- Mechanisms by which the extracellular matrix and integrin signaling act to regulate the switch between tumor suppression and tumor promotion.Journal of mammary gland biology and neoplasia · 2011Review
- β1-integrins signaling and mammary tumor progression in transgenic mouse models: implications for human breast cancer.Breast cancer research : BCR · 2011Review
- Promyelocytic leukemia protein controls cell migration in response to hydrogen peroxide and insulin-like growth factor-1.The Journal of biological chemistry · 2010Article
- Autocrine semaphorin3A stimulates alpha2 beta1 integrin expression/function in breast tumor cells.Breast cancer research and treatment · 2009Article
- Chemical and Biochemical Basis of Cell-Bone Matrix Interaction in Health and Disease.Current chemical biology · 2009Article
- Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo.Cancer research · 2006Article
- Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes.Breast cancer research : BCR · 2004Review
- Expression level of integrin alpha 5 on tumour cells affects the rate of metastasis to the kidney.British journal of cancer · 2003Article
- Activation of the alpha2beta1 integrin prevents c-erbB2-induced scattering and apoptosis of human mammary epithelial cells in collagen.Oncogene · 2000Article
- Integrin function in breast carcinoma progression.Journal of mammary gland biology and neoplasia · 1999Review
- Collagen receptor control of epithelial morphogenesis and cell cycle progression.The American journal of pathology · 1999Article
- Functional cloning of ARM-1, an adhesion-regulating molecule upregulated in metastatic tumor cells.Clinical & experimental metastasis · 1999Article
- Tissue architecture: the ultimate regulator of epithelial function?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1998Review
- Structural cues from the tissue microenvironment are essential determinants of the human mammary epithelial cell phenotype.Journal of mammary gland biology and neoplasia · 1998Review
- Altered integrin expression and the malignant phenotype: the contribution of multiple integrated integrin receptors.Journal of mammary gland biology and neoplasia · 1998Review
- Differentiation and cancer in the mammary gland: shedding light on an old dichotomy.Advances in cancer research · 1998Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The integrin superfamily of adhesion receptors mediates interactions between cells and the extracellular matrix. Our earlier immunohistochemical analysis showed that normal mammary epithelium expressed high levels of the alpha 2 beta 1 collagen/laminin receptor and intermediate levels of the alpha 5 beta 1 fibronectin receptor. In contrast, malignant cells of adenocarcinoma of the breast exhibited marked diminution or loss of the alpha 2 beta 1 and alpha 5 beta 1 integrins. We have now evaluated the level of alpha 2, alpha 5, and beta 1 integrin subunit messenger (m)RNA by in situ hybridization in adenocarcinoma of the breast. Normal breast ducts and ductules expressed high levels of all three integrin subunit mRNAs. Poorly differentiated lesions expressed low to undetectable levels of alpha 2, alpha 5, and beta 1 mRNA. Well- and moderately differentiated lesions expressed all three subunits at intermediate levels. Thus, decreased expression of the alpha 2 beta 1 and alpha 5 beta 1 integrins in mammary carcinoma is the result of decreased steady-state integrin subunit mRNA levels due to altered expression of the integrin genes.
Indexed as
Identifiers
8388172PMC1886906W629619092What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.