ArticleInfection and immunity1993
Kupffer cell elimination enhances development of liver schizonts of Plasmodium berghei in rats.
Article in Infection and immunity, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 46 citations in OpenAlex.
- Pilot trial of intravenous infusion of a replication-selective adenovirus (ONYX-015) in combination with chemotherapy or IL-2 treatment in refractory cancer patients.Cancer gene therapy · 2003Trial
- Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: safety, feasibility and biological activity.Gene therapy · 2001Trial
- Elucidating Spatially-Resolved Changes in Host Signaling DuringFrontiers in cellular and infection microbiology · 2021Article
- The survival of memory CD8 T cells that is mediated by IL-15 correlates with sustained protection against malaria.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Mouse adenovirus type 1 infection of macrophages.Virology · 2009Article
- Depletion of phagocytes in the reticuloendothelial system causes increased inflammation and mortality in rabbits with Pseudomonas aeruginosa pneumonia.American journal of physiology. Lung cellular and molecular physiology · 2009Article
- Exoerythrocytic development of Plasmodium gallinaceum in the White Leghorn chicken.International journal for parasitology · 2008Article
- Article
- Oncolytic viral therapies.Cancer gene therapy · 2004Review
- Cell-passage activity is required for the malarial parasite to cross the liver sinusoidal cell layer.PLoS biology · 2004Article
- Selectively replicating viral vectors.Cancer gene therapy · 2002Review
- gammadelta T cells are a component of early immunity against preerythrocytic malaria parasites.Infection and immunity · 2000Article
- Analysis of host cells associated with the Spv-mediated increased intracellular growth rate of Salmonella typhimurium in mice.Infection and immunity · 1998Article
- Effects of neutrophil, natural killer cell, and macrophage depletion on murine Clostridium piliforme infection.Infection and immunity · 1997Article
- Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ.Journal of virology · 1997Article
- Methods for assessing splenic macrophage depletion by liposome encapsulated clodronate.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 1995Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the development of exoerythrocytic forms (EEF) of Plasmodium berghei in livers of normal and macrophage-depleted Brown Norway rats. Macrophages were depleted by use of liposome-encapsulated dichloromethylene diphosphonate. Upon inoculation of sporozoites, macrophage-depleted rats had significantly larger numbers of EEF than untreated rats. We also investigated the effect of macrophage impairment by silica treatment on the development of EEF and confirmed that silica induces a significant reduction of EEF development. Intravenous administration of silica induced high levels of interleukin-6 in plasma within a few hours. The seemingly contradictory results for EEF development may be explained by our previous observation that interleukin-6 strongly inhibits sporozoite penetration and EEF development in vivo. We conclude that in experimental infections with sporozoites, Kupffer cells inhibit rather than enhance EEF development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.