ArticleThe EMBO journal1993
A dominant-negative transgene defines a role for p56lck in thymopoiesis.
Article in The EMBO journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed, 301 citations in OpenAlex.
- The TCR and LCK: foundations for T-cell activation and therapeutic innovation.Frontiers in immunology · 2025Review
- Type of PaperY192 within the SH2 Domain of Lck Regulates TCR Signaling Downstream of PLC-γ1 and Thymic Selection.International journal of molecular sciences · 2022Article
- Identification of Potential Biomarkers of Type 2 Diabetes Mellitus-Related Immune Infiltration Using Weighted Gene Coexpression Network Analysis.BioMed research international · 2022Article
- Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified.Nature communications · 2021Article
- Interaction of SHP-2 SH2 domains with PD-1 ITSM induces PD-1 dimerization and SHP-2 activation.Communications biology · 2020Article
- Dietary zinc deficiency in rodents: effects on T-cell development, maturation and phenotypes.Nutrients · 2012Review
- Targeted overexpression of an activated N-ras gene results in B-cell and plasma cell lymphoproliferation and cooperates with c-myc to induce fatal B-cell neoplasia.Experimental hematology · 2012Article
- Evaluation of Serum Zinc Level Under Malignant Condition and its Possible Implication on Improving Cell-Mediated Immunity During Cancer Progression.World journal of oncology · 2011Article
- PU.1 regulates TCR expression by modulating GATA-3 activity.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Functional analysis of histone methyltransferase g9a in B and T lymphocytes.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Lck SH3 domain function is required for T-cell receptor signals regulating thymocyte development.Molecular and cellular biology · 2006Article
- Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.Oncogene · 2004Review
- Major T cell progenitor activity in bone marrow-derived spleen colonies.The Journal of experimental medicine · 2002Article
- p56Lck anchors CD4 to distinct microdomains on microvilli.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Characterization of T cell differentiation in the murine gut.The Journal of experimental medicine · 2002Article
- Assessing a role for enhancer-blocking activity in gene regulation within the murine T-cell receptor alpha/delta locus.Immunology · 2001Article
- Autonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk).The Journal of experimental medicine · 2001Article
- Allelic exclusion and differentiation by protein kinase C-mediated signals in immature thymocytes.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- CD28 and the tyrosine kinase lck stimulate mitogen-activated protein kinase activity in T cells via inhibition of the small G protein Rap1.Molecular and cellular biology · 2000Article
- Metabolites from apoptotic thymocytes inhibit thymopoiesis in adenosine deaminase-deficient fetal thymic organ cultures.The Journal of clinical investigation · 2000Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The lymphocyte-specific protein tyrosine kinase p56lck participates in T cell signaling through functional interactions with components of the T cell antigen receptor complex and the interleukin-2 receptor. Additional insight into the function of p56lck has now been obtained through the generation of transgenic animals expressing high levels of a catalytically inactive form of this kinase (p56lckR273). Mice bearing the lckR273 transgene manifested a severe defect in the production of virtually all T lymphocytes. Those exceptional CD3+ cells that escaped the effects of the lckR273 transgene were confined primarily to the T cell subset that expresses gamma/delta T cell receptors. Remarkably, construction of a dose-response curve for the effects of the lckR273 transgene revealed that developmental arrest of thymocytes occurred at a discrete stage in the normal T cell maturation pathway, corresponding to a point at which thymoblasts ordinarily begin a series of mitotic divisions that result in expansion and maturation. These results suggest that p56lck normally regulates T cell production by metering the replicative potential of immature thymoblasts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.