ArticleThe EMBO journal1993
Generation of processed pseudogenes in murine cells.
Article in The EMBO journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 65 citations in OpenAlex.
- Tracing Mobile DNAs: From Molecular to Population Scales.Frontiers in plant science · 2022Review
- The Genomic Impact of Gene Retrocopies: What Have We Learned from Comparative Genomics, Population Genomics, and Transcriptomic Analyses?Genome biology and evolution · 2017Article
- L1 expression and regulation in humans and rodents.Frontiers in bioscience (Elite edition) · 2012Review
- Similarities between long interspersed element-1 (LINE-1) reverse transcriptase and telomerase.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- The L1 retrotransposition assay: a retrospective and toolkit.Methods (San Diego, Calif.) · 2009Review
- TARGeT: a web-based pipeline for retrieving and characterizing gene and transposable element families from genomic sequences.Nucleic acids research · 2009Article
- Human endogenous retrovirus (HERV-K) reverse transcriptase as a breast cancer prognostic marker.Neoplasia (New York, N.Y.) · 2008Article
- The potential regulation of L1 mobility by RNA interference.Journal of biomedicine & biotechnology · 2006Article
- Unusual expression of LINE-1 transposable element in the MRL autoimmune lymphoproliferative syndrome-prone strain.Oncogene · 2002Article
- Processed pseudogenes of human endogenous retroviruses generated by LINEs: their integration, stability, and distribution.Genome research · 2002Article
- Human L1 retrotransposition: cis preference versus trans complementation.Molecular and cellular biology · 2001Article
- Use of molecular beacons to verify that the serine hydroxymethyltransferase pseudogene SHMT-ps1 is unique to the order Primates.Genome biology · 2001Article
- Comparison of complete nuclear receptor sets from the human, Caenorhabditis elegans and Drosophila genomes.Genome biology · 2001Article
- Target specificity of the endonuclease from the Xenopus laevis non-long terminal repeat retrotransposon, Tx1L.Molecular and cellular biology · 2000Article
- Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.Journal of virology · 1999Article
- Retrotransposition of nonviral RNAs in an avian packaging cell line.Journal of virology · 1998Article
- A genetically marked I element in Drosophila melanogaster can be mobilized when ORF2 is provided in trans.Genetics · 1998Article
- Invertebrate retroviruses: ZAM a new candidate in D.melanogaster.The EMBO journal · 1997Article
- Functional differences between the human LINE retrotransposon and retroviral reverse transcriptases for in vivo mRNA reverse transcription.The EMBO journal · 1997Article
- mRNA retroposition in human cells: processed pseudogene formation.The EMBO journal · 1995Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using as a reporter gene a non-coding proviral structure marked with an intron-containing indicator, we demonstrate the de novo formation, via a retrotransposition pathway, of canonical processed pseudogenes in cultured mammalian cells. Their structural features include endings corresponding to the start and termination of the RNA intermediate, intron loss, acquisition of a 3' poly(A) tail, and target site duplications of variable length. The absence of extracellular intermediates for these processes, and the elimination during retrotransposition of sequences in the reporter gene essential in cis for a retroviral cycle, further suggest that endogenous retroviruses or related elements are not involved. Pseudogene formation frequency is markedly increased (up to 10-fold) by several treatments including treatment with 5-azacytidine or tetradecanoyl phorbol acetate, or serum starvation, which do not act at the reporter gene transcription level, but rather on endogenous genes--including the LINE elements--necessarily involved in trans-complementation for retrotransposition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.