ArticleVirchows Archiv. A, Pathological anatomy and histopathology1993
Presence and possible significance of immunocytochemically demonstrable metallothionein over-expression in primary invasive ductal carcinoma of the breast.
Article in Virchows Archiv. A, Pathological anatomy and histopathology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 122 citations in OpenAlex.
- Pooled it
- Expression Levels of DNMT1, HDAC1, and MT1E Genes as Diagnostic Biomarkers for Breast Cancer Clinicopathological Features: In Vitro and In Silico Analyses.Analytical cellular pathology (Amsterdam) · 2026Article
- One Third of Malignant Pleural Mesothelioma Shows High Immunohistochemical Expression of MSLN or CXCR4 Which Indicates Potent Candidates for Endo-Radiotherapy.International journal of molecular sciences · 2023Article
- Tumor cell cytoplasmic metallothionein expression associates with differential tumor immunogenicity and prognostic outcome in high-grade serous ovarian carcinoma.Frontiers in oncology · 2023Article
- Article
- The unique C- and N-terminal sequences of Metallothionein isoform 3 mediate growth inhibition and Vectorial active transport in MCF-7 cells.BMC cancer · 2017Article
- Lack of association between autism and four heavy metal regulatory genes.Neurotoxicology · 2011Article
- Mammary gland zinc metabolism: regulation and dysregulation.Genes & nutrition · 2009Article
- Investigating Multi-cancer Biomarkers and Their Cross-predictability in the Expression Profiles of Multiple Cancer Types.Biomarker insights · 2009Article
- Metallothionein: an overview.World journal of gastroenterology · 2007Review
- [Salivary gland-like tumors of the breast].Der Pathologe · 2006Article
- Metallothionein mediates leukocyte chemotaxis.BMC immunology · 2005Article
- Myoepithelial cells: good fences make good neighbors.Breast cancer research : BCR · 2005Article
- Clinicopathological significance of metallothioneins in breast cancer.Pathology oncology research : POR · 2004Review
- The plasticity of human breast carcinoma cells is more than epithelial to mesenchymal conversion.Breast cancer research : BCR · 2001Review
- Metallothionein 1E mRNA is highly expressed in oestrogen receptor-negative human invasive ductal breast cancer.British journal of cancer · 2000Article
- Correlation of metallothionein expression with apoptosis in nasopharyngeal carcinoma.British journal of cancer · 2000Article
- Prognostic evaluation of metallothionein expression in human colorectal neoplasms.Journal of clinical pathology · 1999Article
- Metallothionein expression correlates with metastatic and proliferative potential in squamous cell carcinoma of the oesophagus.British journal of cancer · 1999Article
- Prognostic value of immunoexpression of the chemoresistance-related proteins in ependymomas: an analysis of 76 cases.Journal of neuro-oncology · 1999Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metallothioneins (MTs) are ubiquitous low-molecular-weight proteins with a high affinity for heavy metal ions such as zinc, copper and cadmium. MT over-expression has been associated with resistance against anticancer drugs. In the present study we investigated 86 cases (45 cases of tumour category pT1 and 41 of category pT2) of routinely fixed and paraffin-embedded primary breast carcinomas immunohistochemically with a monoclonal antibody to an epitope of MT shared by its I and II isoforms. Immunohistochemically demonstrated MT over-expression was found in the invasive components of 7 of 32 pT1 and 17 of 28 pT2 invasive ductal carcinomas, whereas all 26 invasive lobular carcinomas gave weak or negative results. Fourteen of 17 pT2 and 2 of 7 pT1 invasive ductal carcinomas with MT over-expression developed metastases during follow-up with poor prognostic outcome. In contrast only 3 of 11 pT2 and none of the 25 pT1 cases without MT over-expression had a poor clinical course (P < 0.001). It is concluded that MT over-expression is associated with significantly poor prognosis particularly in pT2 invasive ductal breast carcinomas.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.