ArticleProceedings of the National Academy of Sciences of the United States of America1993
Molecular cloning and characterization of a cDNA showing negative regulation in v-src-transformed 3Y1 rat fibroblasts.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 69 citations in OpenAlex.
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- Blood Flow Disturbances in Congenital Heart Disease: Is Neuroblastoma Suppressor of Tumorigenicity 1 a Target for Preventing Pulmonary Vascular Remodeling?American journal of respiratory cell and molecular biology · 2022Article
- DAN (NBL1) promotes collective neural crest migration by restraining uncontrolled invasion.The Journal of cell biology · 2017Article
- Inhibitory effect of NBL1 on PDGF-BB-induced human PASMC proliferation through blockade of PDGFβ-p38MAPK pathway.Bioscience reports · 2016Article
- Agonists and Antagonists of TGF-β Family Ligands.Cold Spring Harbor perspectives in biology · 2016Review
- Calpain regulates thymidylate synthase-5-fluoro-dUMP complex levels associated with response to 5-fluorouracil in gastric cancer cells.Cancer science · 2011Article
- GnRH-mediated DAN production regulates the transcription of the GnRH receptor in gonadotrope cells.Neuromolecular medicine · 2007Article
- Purification and partial amino acid sequence of proteins from human epidermal keratinocyte conditioned medium.Journal of protein chemistry · 2001Article
- Mutation and analysis of Dan, the founding member of the Dan family of transforming growth factor beta antagonists.Molecular and cellular biology · 2001Article
- Isolation of transformation suppressor genes by cDNA subtraction: lumican suppresses transformation induced by v-src and v-K-ras.Journal of virology · 2000Article
- Article
- Suppression of v-src transformation by the drs gene.Journal of virology · 1998Article
- Identification of drm, a novel gene whose expression is suppressed in transformed cells and which can inhibit growth of normal but not transformed cells in culture.Molecular and cellular biology · 1997Article
- Expression of secreted platelet-derived growth factor-B by recombinant nonreplicating and noncytopathic vaccina virus.Annals of surgery · 1996Article
- Chromosome mapping of the mouse and rat homologs of the human DAN gene, D1S1733E.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- Transcriptional down regulation of the nov proto-oncogene in fibroblasts transformed by p60v-src.Molecular and cellular biology · 1996Article
- Cloning of mouse DAN cDNA and its down-regulation in transformed cells.Japanese journal of cancer research : Gann · 1996Article
- Involvement of S100-related calcium-binding protein pEL98 (or mts1) in cell motility and tumor cell invasion.Japanese journal of cancer research : Gann · 1994Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A differential screening procedure was used to isolate genes that are specifically down-regulated in transformed cells. After screening a cDNA library derived from normal rat fibroblast (3Y1) cells, we obtained several independent cDNAs whose mRNA level was substantially lower in 3Y1 cells transformed with Rous sarcoma virus than in untransformed 3Y1 cells. Among them, N03 cDNA has been characterized extensively. N03 mRNA was also absent from v-mos- or simian virus 40-transformed 3Y1 cells but was present in v-Ha-ras-transformed 3Y1 cells. Nucleotide sequence analysis showed that the N03 protein is composed of 178 amino acid residues and does not have any sequence similarities with proteins in the data base. A putative zinc-finger domain is located in the central part of the sequence and a proline-rich domain is in the C-terminal region. N03 mRNA was detected by Northern blot analysis in several tissues, including lung, kidney, intestine, and brain, but not in liver. Genomic Southern blot hybridization revealed that the N03 gene exists as a single copy in the rat genome and that closely related, single-copy genes are also present in chicken and human.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.