ArticleAntimicrobial agents and chemotherapy1993
Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.
Article in Antimicrobial agents and chemotherapy, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.
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Who cites it
112 citing papers in PubMed.
- Virulence and Antimicrobial Resistance inAntibiotics (Basel, Switzerland) · 2026Review
- Analysis of GyrA gene mutations in environmental Escherichia coli: understanding the mechanisms and spread of quinolone resistance in ecosystems.Die Naturwissenschaften · 2026Article
- Longitudinal survey investigating vectors and reservoirs forApplied and environmental microbiology · 2025Article
- Population Structure and Antimicrobial Resistance in Campylobacter jejuni and C. coli Isolated from Humans with Diarrhea and from Poultry, East Africa.Emerging infectious diseases · 2024Article
- Genetic Diversity, Virulence, and Antibiotic Resistance Determinants ofPathogens (Basel, Switzerland) · 2024Article
- Fluoroquinolone-resistantJAC-antimicrobial resistance · 2024Article
- Whole-Genome and Plasmid Comparative Analysis of Campylobacter jejuni from Human Patients in Toyama, Japan, from 2015 to 2019.Microbiology spectrum · 2023Article
- Growth kinetics and fitness of fluoroquinolone resistant and susceptibleFrontiers in veterinary science · 2023Article
- Droplet Digital PCR-Based Detection and Quantification of GyrA Thr-86-Ile Mutation Based Fluoroquinolone-Resistant Campylobacter jejuni.Microbiology spectrum · 2022Article
- Isolation and characterization of thermophilicIranian journal of veterinary research · 2022Article
- Differences in Genotype and Antimicrobial Resistance betweenPathogens (Basel, Switzerland) · 2021Article
- Exposure of Salmonella biofilms to antibiotic concentrations rapidly selects resistance with collateral tradeoffs.NPJ biofilms and microbiomes · 2021Article
- Resistance to Antibiotics in Thermophilic Campylobacters.Frontiers in medicine · 2021Review
- Natural Horizontal Gene Transfer of Antimicrobial Resistance Genes inFrontiers in microbiology · 2021Article
- Susceptibility ofAntibiotics (Basel, Switzerland) · 2020Article
- Validation of the T86I mutation in the gyrA gene as a highly reliable real time PCR target to detect Fluoroquinolone-resistant Campylobacter jejuni.BMC infectious diseases · 2020Article
- Microevolution of Campylobacter jejuni during long-term infection in an immunocompromised host.Scientific reports · 2020Article
- Investigating Major RecurringFrontiers in cellular and infection microbiology · 2020Article
- Genomic Analysis Reveals the Genetic Determinants Associated With Antibiotic Resistance in the Zoonotic PathogenFrontiers in microbiology · 2020Article
- Acquisition of fluoroquinolone resistance leads to increased biofilm formation and pathogenicity in Campylobacter jejuni.Scientific reports · 2019Article
52 more citing papers are in PubMed but not listed here.
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3 authors.
Funding
Abstract
The gyrA gene of Campylobacter jejuni UA580, which encodes the A subunit of DNA gyrase, was cloned and its nucleotide sequence was determined. An open reading frame of 2,589 nucleotides was identified, which could code for a polypeptide of 863 amino acids with a M(r) of 97 kDa. Both the nucleotide sequence and the putative amino acid sequence show ca. 50% identity with those of other gyrA genes from gram-positive and gram-negative bacteria. The locations of the gyrA gene on genome maps of both C. jejuni UA580 and Campylobacter coli UA417 were determined. Six nalidixic acid-resistant isolates of C. jejuni were shown to carry mutations in gyrA. Three clinical isolates had Thr-86-to-Ile substitutions. Three laboratory mutants had substitutions of Thr-86 to Ile, Asp-90 to Ala, and Ala-70 to Thr, respectively. The mutation at Thr-86, which is homologous to Ser-83 in Escherichia coli, was associated with high-level resistance to ciprofloxacin in C. jejuni.
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