ArticleProceedings of the National Academy of Sciences of the United States of America1993
Retroviral infection coupled with tissue transplantation limits gene transfer in the chicken embryo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- Screening of nontoxic dyes for improved visualization and success rate in mouse embryo transfer.Laboratory animal research · 2025Article
- Article
- Stable integration of an optimized inducible promoter system enables spatiotemporal control of gene expression throughout avian development.Biology open · 2020Article
- miR-199 family contributes to regulation of sonic hedgehog expression during craniofacial development.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Article
- Neural crest and the origin of species-specific pattern.Genesis (New York, N.Y. : 2000) · 2018Review
- The chick embryo as an expanding experimental model for cancer and cardiovascular research.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Review
- Rediscovering the chick embryo as a model to study retinal development.Neural development · 2012Review
- Repulsive guidance molecule plays multiple roles in neuronal differentiation and axon guidance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Two different molecular defects in the Tva receptor gene explain the resistance of two tvar lines of chickens to infection by subgroup A avian sarcoma and leukosis viruses.Journal of virology · 2004Article
- Loss-of-function analysis of EphA receptors in retinotectal mapping.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Evolutionary pressure of a receptor competitor selects different subgroup a avian leukosis virus escape variants with altered receptor interactions.Journal of virology · 2003Article
- Novel monoclonal antibody directed at the receptor binding site on the avian sarcoma and leukosis virus Env complex.Journal of virology · 2002Article
- Regulated gene expression in the chicken embryo by using replication-competent retroviral vectors.Journal of virology · 2002Article
- Identification of key residues in subgroup A avian leukosis virus envelope determining receptor binding affinity and infectivity of cells expressing chicken or quail Tva receptor.Journal of virology · 2001Article
- Soluble forms of the subgroup A avian leukosis virus [ALV(A)] receptor Tva significantly inhibit ALV(A) infection in vitro and in vivo.Journal of virology · 1999Article
- Replication-competent retroviral vectors for expressing genes in avian cells in vitro and in vivo.Molecular biotechnology · 1997Review
- Chondrocytes as a specific target of ectopic Fos expression in early development.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Cartilage matrix protein forms a type II collagen-independent filamentous network: analysis in primary cell cultures with a retrovirus expression system.Molecular biology of the cell · 1995Article
- Vectors derived from avian leukosis and sarcoma viruses.Journal of molecular medicine (Berlin, Germany) · 1995Review
- Replication-competent retroviral vectors encoding alkaline phosphatase reveal spatial restriction of viral gene expression/transduction in the chick embryo.Molecular and cellular biology · 1993Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Gene transfer into early embryos is a powerful methodology for unraveling the molecular bases of developmental processes. One can attempt to minimize widespread effects of an exogenous gene by using tissue- or region-specific promoters in the few instances where they are available. We have developed a method that bypasses the requirement for specific targeting sequences to achieve regionally restricted gene transfer. Intraspecific chimeras have been created by transplantation of restricted portions of a chicken embryo from a donor strain to a host strain. The donor cells are infectable with a recombinant retroviral vector that carries the exogenous gene, whereas the host cells are not. We have demonstrated the feasibility of this approach using a histochemically distinct reporter gene, human placental alkaline phosphatase. The expression of retrovirally transduced alkaline phosphatase was limited to a transplanted hemiprosencephalon (forebrain and eye) in embryonic chickens. This technique can be applied to many other organ systems during avian embryogenesis to test the function(s) of molecules that are normally controlled through spatial and/or temporal regulation, such as many of the growth factor receptors or homeobox-containing proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.