ArticleInfection and immunity1993
Phagocytosis of Staphylococcus aureus induces a selective stress response in human monocytes-macrophages (M phi): modulation by M phi differentiation and by iron.
Article in Infection and immunity, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 52 citations in OpenAlex.
- Synergistic effects of toxic elements on heat shock proteins.BioMed research international · 2014Review
- The HSP72 stress response of monocytes from patients on haemodialysis is impaired.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2009Article
- Cytoprotective effects of geranylgeranylacetone against retinal photooxidative damage.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Role of HSP70i in regulation of biomaterial-induced activation of human monocytes-derived macrophages in culture.Journal of materials science. Materials in medicine · 2001Article
- Heat-shocked monocytes are resistant to Staphylococcus aureus-induced apoptotic DNA fragmentation due to expression of HSP72.Infection and immunity · 1999Article
- Oxidative stress in toxicology: established mammalian and emerging piscine model systems.Environmental health perspectives · 1998Review
- Phagocytosis of Pseudomonas aeruginosa fails to elicit heat shock protein expression in human monocytes.Inflammation · 1996Article
- Induction of heat shock proteins and their possible roles in macrophages during activation by macrophage colony-stimulating factor.The Biochemical journal · 1996Article
- Differential induction of stress proteins and functional effects of heat shock in human phagocytes.Inflammation · 1995Article
- Hsp70--a multi-gene, multi-structure, multi-function family with potential clinical applications.Experientia · 1994Review
- Host cell responses to Listeria monocytogenes infection include differential transcription of host stress genes involved in signal transduction.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- In vitro Superoxide Production by Peripheral Neutrophils from Patients with Inflammatory Bowel Disease.Mediators of inflammation · 1994Article
- Effects of the Bacterial Extract OM-85 on Phagocyte Functions and the Stress Response.Mediators of inflammation · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phagocytosis of microorganisms represents a stress not only for the phagocytosed agent but also for the host cell. We have investigated the stress response induced in human monocytes-macrophages (M phi) phagocytosing inactivated Staphylococcus aureus. Exposure of human M phi to S. aureus induced in these cells (i) a threefold increase in superoxide dismutase activity, (ii) a selective and differentiation-dependent induction of host heat shock protein synthesis (HSP70 but not HSP65), and (iii) de novo synthesis of heme oxygenase, but only when exogenous iron was added to the cultures. The coordinate upregulation of two scavenging enzymes and of HSP70 suggests that all three are part of cellular protective mechanisms against phagocytosis-related oxidative injury to host cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.