ArticleNucleic acids research1993
Specific gene transfer mediated by lactosylated poly-L-lysine into hepatoma cells.
Article in Nucleic acids research, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 287 citations in OpenAlex.
- Novel tumour antigens and the development of optimal vaccine design.Therapeutic advances in vaccines and immunotherapy · 2018Review
- Functional peptides for siRNA delivery.Advanced drug delivery reviews · 2017Review
- Structure Dependence of Lysosomal Transit of Chitosan-Based Polyplexes for Gene Delivery.Molecular biotechnology · 2016Article
- Recent trends of polymer mediated liposomal gene delivery system.BioMed research international · 2014Review
- NTS-Polyplex: a potential nanocarrier for neurotrophic therapy of Parkinson's disease.Nanomedicine : nanotechnology, biology, and medicine · 2012Review
- Rational design, fabrication, characterization and in vitro testing of biodegradable microparticles that generate targeted and sustained transgene expression in HepG2 liver cells.Journal of drug targeting · 2011Article
- Advances in polymeric and inorganic vectors for nonviral nucleic acid delivery.Therapeutic delivery · 2011Review
- Polymeric carriers for gene delivery: chitosan and poly(amidoamine) dendrimers.Current pharmaceutical design · 2010Review
- NT-polyplex: a new tool for therapeutic gene delivery to neuroblastoma tumors.Cancer gene therapy · 2009Article
- Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers.British journal of pharmacology · 2009Review
- Hexa-arginine enhanced uptake and residualization of selective high affinity ligands by Raji lymphoma cells.Molecular cancer · 2009Article
- Nano-vectors for efficient liver specific gene transfer.International journal of nanomedicine · 2008Review
- Glycotargeting to improve cellular delivery efficiency of nucleic acids.Glycoconjugate journal · 2007Review
- Design and development of polymers for gene delivery.Nature reviews. Drug discovery · 2005Review
- Polyethylene glycol-conjugated copolymers for plasmid DNA delivery.Pharmaceutical research · 2005Review
- Negatively charged self-assembling DNA/poloxamine nanospheres for in vivo gene transfer.Nucleic acids research · 2004Article
- Peptides containing antigenic and cationic domains have enhanced, multivalent immunogenicity when bound to DNA vaccines.Journal of molecular medicine (Berlin, Germany) · 2004Article
- Water-soluble lipopolymer as an efficient carrier for gene delivery to myocardium.Gene therapy · 2003Article
- Intracellular rate-limiting steps of gene transfer using glycosylated polylysines in cystic fibrosis airway epithelial cells.Gene therapy · 2002Article
- Targeting of cell receptors and gene transfer efficiency: a balancing act.Gene therapy · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plasmid DNA/glycosylated polylysine complexes were used to transfer in vitro a luciferase reporter gene into human hepatoma cells by a receptor-mediated endocytosis process. HepG2 cells which express a galactose specific membrane lectin were efficiently and selectively transfected with pSV2Luc/lactosylated polylysine complexes in a sugar dependent manner: i) HepG2 cells which do not express membrane lectin specific for mannose were quite poorly transfected with pSV2Luc/mannosylated polylysine complexes, ii) HeLa cells which do not express membrane lectin specific for galactose were not transfected with pSV2Luc/lactosylated polylysine complexes. The transfection efficiency of HepG2 cells with pSV2Luc/lactosylated polylysine complexes was greatly enhanced either in the presence of chloroquine or in the presence of a fusogenic peptide. A 22-residue peptide derived from the influenza virus hemagglutinin HA2 N-terminal polypeptide that mimics the fusogenic activity of the virus, was selected. In the presence of the fusogenic peptide, the luciferase activity in HepG2 cells was 10 fold larger than that of cells transfected with pSV2Luc/lactosylated polylysine complexes in the presence of chloroquine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.