ArticleThe Journal of clinical investigation1993
Iron sequestration by macrophages decreases the potential for extracellular hydroxyl radical formation.
Article in The Journal of clinical investigation, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 66 citations in OpenAlex.
- Targeting macrophage ferritin heavy chain mitigates ferroptosis and lung injury in experimental acute respiratory distress syndrome.Nature communications · 2026Article
- Targeted deletion of macrophage ferritin heavy chain protects from macrophage ferroptosis in acute respiratory distress syndrome.Research square · 2026Article
- Lung microhaemorrhage drives oxidative/inflammatory damage in αERJ open research · 2023Article
- Anti-Inflammatory, Antinociceptive, and Antioxidant Properties of Anacardic Acid in Experimental Models.ACS omega · 2020Article
- Iron Homeostasis in the Lungs-A Balance between Health and Disease.Pharmaceuticals (Basel, Switzerland) · 2019Review
- Article
- TLR4 Deficiency Impairs Oligodendrocyte Formation in the Injured Spinal Cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Increased iron sequestration in alveolar macrophages in chronic obstructive pulmonary disease.PloS one · 2014Article
- Systemic iron chelation results in limited functional and histological recovery after traumatic spinal cord injury in rats.Experimental neurology · 2013Article
- Increased Lysosomal Membrane Permeabilization in Oxidant-exposed Macrophages of Human Fibrotic Lungs.Journal of cell death · 2013Article
- Leaky lysosomes in lung transplant macrophages: azithromycin prevents oxidative damage.Respiratory research · 2012Article
- Iron accumulation in bronchial epithelial cells is dependent on concurrent sodium transport.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2008Article
- Inorganic dust pneumonias: the metal-related parenchymal disorders.Environmental health perspectives · 2000Review
- Role of iron in Nramp1-mediated inhibition of mycobacterial growth.Infection and immunity · 1999Article
- Iron metabolism in the lower respiratory tract.Thorax · 1998Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Alveolar macrophages (AM) from smokers contain a much higher quantity of intracellular iron than AM from nonsmokers. Since some forms of iron will catalyze the formation of hydroxyl radical (.OH) from superoxide and hydrogen peroxide, the ability of AM derived from smokers and nonsmokers to generate .OH was assessed. No detectable .OH was produced by AM from either source, suggesting that iron sequestration by AM may limit the potential for .OH-mediated lung injury. Consistent with this hypothesis, the ability of bronchoalveolar lavage fluid (BAL) from smokers and nonsmokers to act as an .OH catalyst decreased after exposure to AM. We found that, like AM, human monocyte-derived macrophages (MDM) have the ability to acquire large quantities of iron from small low molecular weight iron chelates as well as decrease the ability of BAL to act as a .OH catalyst. When MDM or AM were exposed to the iron chelates or BAL they were then able to generate .OH after phorbol myristate acetate stimulation. However, when acutely iron-loaded or BAL-exposed MDM were placed in culture, their ability to produce .OH decreased with time to the level of non-iron-exposed controls. This process correlated with iron translocation from the plasma membrane to the cytosol as well as a 3-9-fold increase in cellular ferritin. No increase in antioxidant enzyme levels or induction of the heat shock response was observed. Iron sequestration by macrophages may protect nearby cells from exposure to potentially cytotoxic iron-catalyzed oxidants such as .OH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.