ArticleBritish journal of pharmacology1993
Investigation into the role of phosphodiesterase IV in bronchorelaxation, including studies with human bronchus.
Article in British journal of pharmacology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 113 citations in OpenAlex.
- Clinical Relevance of the Anti-inflammatory Effects of Roflumilast on Human Bronchus: Potentiation by a Long-Acting Beta-2-Agonist.Frontiers in pharmacology · 2020Article
- Novel relaxant effects of RPL554 on guinea pig tracheal smooth muscle contractility.British journal of pharmacology · 2016Article
- The relevance of theobromine for the beneficial effects of cocoa consumption.Frontiers in pharmacology · 2015Article
- Theophylline inhibits the cough reflex through a novel mechanism of action.The Journal of allergy and clinical immunology · 2014Article
- New therapeutic options in the management of COPD - focus on roflumilast.International journal of chronic obstructive pulmonary disease · 2011Review
- Treating COPD with PDE 4 inhibitors.International journal of chronic obstructive pulmonary disease · 2007Review
- Phosphodiesterase inhibitors.British journal of pharmacology · 2006Review
- The combination of PRRS virus and bacterial endotoxin as a model for multifactorial respiratory disease in pigs.Veterinary immunology and immunopathology · 2004Review
- The effect of selective and non-selective phosphodiesterase inhibitors on allergen- and leukotriene C(4)-induced contractions in passively sensitized human airways.British journal of pharmacology · 2000Article
- Bronchodilator and anti-inflammatory activities of glaucine: In vitro studies in human airway smooth muscle and polymorphonuclear leukocytes.British journal of pharmacology · 1999Article
- Effects of SCA40 on human isolated bronchus and human polymorphonuclear leukocytes: comparison with rolipram, SKF94120 and levcromakalim.British journal of pharmacology · 1996Article
- Effects of RP 73401, a novel, potent and selective phosphodiesterase type 4 inhibitor, on contractility of human, isolated bronchial muscle.British journal of pharmacology · 1996Article
- Inhibition of bronchospasm and ozone-induced airway hyperresponsiveness in the guinea-pig by CDP840, a novel phosphodiesterase type 4 inhibitor.British journal of pharmacology · 1996Article
- Review
- Effects of selective phosphodiesterase inhibitors on platelet-activating factor- and antigen-induced airway hyperreactivity, eosinophil accumulation, and microvascular leakage in guinea pigs.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- Functional, biochemical and morphological studies on human bronchi after cryopreservation.British journal of pharmacology · 1995Article
- Vasorelaxant effect of isoliquiritigenin, a novel soluble guanylate cyclase activator, in rat aorta.British journal of pharmacology · 1995Article
- Pulmonary effects of type V cyclic GMP specific phosphodiesterase inhibition in the anaesthetized guinea-pig.British journal of pharmacology · 1994Article
- Relaxation of guinea-pig trachea by cyclic AMP phosphodiesterase inhibitors and their enhancement by sodium nitroprusside.British journal of pharmacology · 1994Article
- Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. We have investigated the role of cyclic nucleotide phosphodiesterase IV (PDE IV) in the relaxation of human bronchus and guinea-pig trachea in vitro and in guinea-pigs in vivo. 2. Functional studies showed that the selective PDE IV inhibitors, rolipram and denbufylline, relaxed human and guinea-pig preparations in vitro. 3. Two clinically used xanthine non-selective PDE inhibitors, theophylline and pentoxifylline, were also effective in these preparations, but were much less potent than the selective agents used. 4. The rank order of potency for the four PDE inhibitors in both species was similar. 5. Biochemical studies indicated that PDE IV was the major PDE isoform present in the human bronchial tissue. PDEs I, II and V were also identified. 6. Theophylline and pentoxifylline were, as expected, non-selective inhibitors of the human enzymes, but there was a good correlation between PDE IV inhibitory and bronchorelaxation potencies, suggesting that PDE IV inhibition is important for the clinical bronchodilator activities of the two xanthine compounds. 7. We have confirmed the ability of selective PDE IV inhibitors to cause bronchodilatation in guinea-pigs in vivo. 8. We conclude that our study has provided further evidence that selective PDE IV inhibitors could act as bronchodilators in the clinic.
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