ArticleNucleic acids research1993
Transcription regulation by murine B-myb is distinct from that by c-myb.
Article in Nucleic acids research, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 73 citations in OpenAlex.
- B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Article
- MYBL2, a link between proliferation and differentiation in maturing colon epithelial cells.Journal of cellular physiology · 2011Article
- B-Myb is critical for proper DNA duplication during an unperturbed S phase in mouse embryonic stem cells.Stem cells (Dayton, Ohio) · 2010Article
- Differential modulation of Myb family genes by Ets-2.Oncogene · 2004Article
- B-Myb overcomes a p107-mediated cell proliferation block by interacting with an N-terminal domain of p107.Oncogene · 2002Article
- The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT.Molecular and cellular biology · 2002Article
- The highly conserved DNA-binding domains of A-, B- and c-Myb differ with respect to DNA-binding, phosphorylation and redox properties.Nucleic acids research · 2001Article
- Article
- c-Myb binds to a sequence in the proximal region of the RAG-2 promoter and is essential for promoter activity in T-lineage cells.Molecular and cellular biology · 2000Article
- Transcriptional repression by AtMYB4 controls production of UV-protecting sunscreens in Arabidopsis.The EMBO journal · 2000Article
- Degradation of B-Myb by ubiquitin-mediated proteolysis: involvement of the Cdc34-SCF(p45Skp2) pathway.Oncogene · 2000Article
- Physical interaction between CDK9 and B-Myb results in suppression of B-Myb gene autoregulation.Oncogene · 2000Article
- Regulation of B-Myb activity by cyclin D1.Oncogene · 2000Article
- Review
- Multiple functions within the Epstein-Barr virus EBNA-3A protein.Journal of virology · 1998Article
- The AmMYB308 and AmMYB330 transcription factors from antirrhinum regulate phenylpropanoid and lignin biosynthesis in transgenic tobaccoThe Plant cell · 1998Article
- The C-terminal domain of B-Myb acts as a positive regulator of transcription and modulates its biological functions.Molecular and cellular biology · 1998Article
- Epstein-Barr virus EBNA3C represses Cp, the major promoter for EBNA expression, but has no effect on the promoter of the cell gene CD21.Journal of virology · 1997Article
- A-myb is expressed in bovine vascular smooth muscle cells during the late G1-to-S phase transition and cooperates with c-myc to mediate progression to S phase.Molecular and cellular biology · 1997Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcription regulatory properties of murine B-myb protein were compared to those of c-myb. Whereas c-Myb trans-activated an SV40 early promoter containing multiple copies of an upstream c-Myb DNA-binding site (MBS-1), and similarly the human c-myc promoter, B-Myb was unable to do so. Full-length B-Myb translated in vitro did not bind MBS-1; however, truncation of the B-Myb C-terminus or fusion of the B-Myb DNA-binding domain to the c-Myb C-terminus showed that it was inherently competent to interact with this motif. Further evidence from co-transfection experiments, demonstrating that B-Myb inhibited trans-activation by c-Myb, suggested that failure of B-Myb to trans-activate these promoters did not simply occur through lack of binding to MBS-1. Moreover, using GAL4/B-Myb fusions, it was found that an acidic region of B-Myb, which by comparison to c-Myb was expected to contain a transcription activation domain, actually had no inherent trans-activation activity and indeed appeared to trans-inhibit c-Myb. In contrast to the above findings, both B-Myb and c-Myb were able to weakly trans-activate the DNA polymerase alpha promoter. Results obtained here demonstrate that the activities of B-Myb and c-Myb are clearly distinct and suggest that these related proteins may have different functions in regulation of target gene expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.