ArticleNucleic acids research1993
A variant Tc4 transposable element in the nematode C. elegans could encode a novel protein.
Article in Nucleic acids research, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Transposon-mediated genic rearrangements underlie variation in small RNA pathways.Science advances · 2024Article
- Article
- Continuous exchange of sequence information between dispersed Tc1 transposons in the Caenorhabditis elegans genome.Genetics · 2003Article
- Transposons but not retrotransposons are located preferentially in regions of high recombination rate in Caenorhabditis elegans.Genetics · 2000Article
- The allele-specific suppressor sup-39 alters use of cryptic splice sites in Caenorhabditis elegans.Genetics · 2000Article
- A transposon-based strategy for sequencing repetitive DNA in eukaryotic genomes.Genome research · 1997Article
- Members of the pogo superfamily of DNA-mediated transposons in the human genome.Molecular & general genetics : MGG · 1996Article
- emo-1, a Caenorhabditis elegans Sec61p gamma homologue, is required for oocyte development and ovulation.The Journal of cell biology · 1996Article
- Tiggers and DNA transposon fossils in the human genome.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Splicing removes the Caenorhabditis elegans transposon Tc1 from most mutant pre-mRNAs.Molecular and cellular biology · 1996Article
- Article
- Article
- AU-rich intronic elements affect pre-mRNA 5' splice site selection in Drosophila melanogaster.Molecular and cellular biology · 1993Article
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2 authors.
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Abstract
A variant C. elegans Tc4 transposable element, Tc4-rh1030, has been sequenced and is 3483 bp long. The Tc4 element that had been analyzed previously is 1605 bp long, consists of two 774-bp nearly perfect inverted terminal repeats connected by a 57-bp loop, and lacks significant open reading frames. In Tc4-rh1030, by comparison, a 2343-bp novel sequence is present in place of a 477-bp segment in one of the inverted repeats. The novel sequence of Tc4-rh1030 is present about five times per haploid genome and is invariably associated with Tc4 elements; we have used the designation Tc4v to denote this variant subfamily of Tc4 elements. Sequence analysis of three cDNA clones suggests that a Tc4v element contains at least five exons that could encode a novel basic protein of 537 amino acid residues. On northern blots, a 1.6-kb Tc4v-specific transcript was detected in the mutator strain TR679 but not in the wild-type strain N2; Tc4 elements are known to transpose in TR679 but appear to be quiescent in N2. We have analyzed transcripts produced by an unc-33 gene that has the Tc4-rh1030 insertional mutation in its transcribed region; all or almost all of the Tc4v sequence is frequently spliced out of the mutant unc-33 transcripts, sometimes by means of non-consensus splice acceptor sites.
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