ArticleMolecular and cellular biology1993
A mitogen-responsive promoter region that is synergistically activated through multiple signalling pathways.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 37 citations in OpenAlex.
- HMGB1 regulates erastin-induced ferroptosis via RAS-JNK/p38 signaling in HL-60/NRASAmerican journal of cancer research · 2019Article
- PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells.Chemistry & biology · 2008Article
- Liver iron transport.World journal of gastroenterology · 2007Review
- Inhibition of transferrin receptor 1 transcription by a cell density response element.The Biochemical journal · 2005Article
- Expression of constitutively active 4EBP-1 enhances p27Kip1 expression and inhibits proliferation of MCF7 breast cancer cells.Cancer cell international · 2003Article
- Role of Ets-1 in transcriptional regulation of transferrin receptor and erythroid differentiation.Oncogene · 2002Article
- Control of cyclin-dependent kinase inhibitor p27 expression by cap-independent translation.Molecular and cellular biology · 2001Article
- The cyclin-dependent kinase inhibitor p27Kip1 is localized to the cytosol in Swiss/3T3 cells.Oncogene · 1999Article
- A DNA-binding activity, TRAC, specific for the TRA element of the transferrin receptor gene copurifies with the Ku autoantigen.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A regulatory region of the human transferrin receptor gene promoter was found to be required for increased expression in response to serum or growth factors. This region contains two elements that appear to cooperate for full responsiveness. We found that sodium orthovanadate treatment of cells significantly activated expression of promoter constructs containing these elements. 12-O-Tetradecanoylphorbol-13-acetate alone induced a twofold increase in expression but acted synergistically with vanadate to generate a highly elevated level of expression. Dibutyryl cyclic AMP alone had no effect on expression, but when added together with vanadate and 12-O-tetradecanoylphorbol-13-acetate, led to superinduction of the promoter construct. Induction of expression by these reagents was delayed several hours, and the kinetics were identical to those observed for serum induction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.