ArticleThe EMBO journal1993
Cell surface control of the multiubiquitination and deubiquitination of high-affinity immunoglobulin E receptors.
Article in The EMBO journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 116 citations in OpenAlex.
- Regulation of fc receptor endocytic trafficking by ubiquitination.Frontiers in immunology · 2014Review
- The architectural relationship of components controlling mast cell endocytosis.Journal of cell science · 2013Article
- Endosomal trafficking of the ligated FcvarepsilonRI receptor.Molecular immunology · 2009Article
- Lipid raft-dependent FcepsilonRI ubiquitination regulates receptor endocytosis through the action of ubiquitin binding adaptors.PloS one · 2009Article
- Differential dephosphorylation of the FcRgamma immunoreceptor tyrosine-based activation motif tyrosines with dissimilar potential for activating Syk.The Journal of biological chemistry · 2008Article
- Detection of a novel unglycosylated form of hepatitis C virus E2 envelope protein that is located in the cytosol and interacts with PKR.Journal of virology · 2002Article
- Contrasting requirements for ubiquitylation during Fc receptor-mediated endocytosis and phagocytosis.The EMBO journal · 2002Article
- Ubiquitination and degradation of Syk and ZAP-70 protein tyrosine kinases in human NK cells upon CD16 engagement.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Deubiquitination step in the endocytic pathway of yeast plasma membrane proteins: crucial role of Doa4p ubiquitin isopeptidase.Molecular and cellular biology · 2001Article
- Raft-partitioning of the ubiquitin ligases Cbl and Nedd4 upon IgE-triggered cell signaling.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- courtless, the Drosophila UBC7 homolog, is involved in male courtship behavior and spermatogenesis.Genetics · 2000Article
- Identification of a novel ubiquitin conjugation motif, required for ligand-induced internalization of the growth hormone receptor.The EMBO journal · 1999Article
- Cell wall and secreted proteins of Candida albicans: identification, function, and expression.Microbiology and molecular biology reviews : MMBR · 1998Review
- Ubiquitin-like polypeptide conjugates to acceptor proteins in concanavalin A- and interferon gamma-stimulated T-cells.The Biochemical journal · 1998Article
- Role for the ubiquitin-proteasome system in the vacuolar degradation of Ste6p, the a-factor transporter in Saccharomyces cerevisiae.Molecular and cellular biology · 1998Article
- The Ras-specific exchange factors mouse Sos1 (mSos1) and mSos2 are regulated differently: mSos2 contains ubiquitination signals absent in mSos1.Molecular and cellular biology · 1997Article
- Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination.The EMBO journal · 1997Article
- The linker region of the ABC-transporter Ste6 mediates ubiquitination and fast turnover of the protein.The EMBO journal · 1997Article
- Actin-, myosin- and ubiquitin-dependent endocytosis.Experientia · 1996Review
- Ubiquitin-like epitopes associated with Candida albicans cell surface receptors.Infection and immunity · 1996Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiubiquitination of proteins is a critical step leading to selective degradation for many polypeptides. Therefore, activation-induced multiubiquitination of cell surface receptors, such as the platelet-derived growth factor (PDGF) receptor and the T cell antigen (TCR) receptor, may correspond to a degradation pathway for ligand-receptor complexes. Here we show that the antigen-induced engagement of high-affinity immunoglobulin E receptors (Fc epsilon RI) results in the immediate multiubiquitination of Fc epsilon RI beta and gamma chains. This ubiquitination is independent of receptor phosphorylation and is restricted to activated receptors. Surprisingly, receptor multiubiquitination is immediately reversible when receptors are disengaged. Therefore, multiubiquitination and deubiquitination of Fc epsilon RI receptors is controlled at the cell surface by receptor engagement and disengagement. The rapidity, specificity and, most importantly, the reversibility of the activation-induced receptor multiubiquitination suggest that this process may turn on/off a cell surface receptor signaling function thus far unsuspected.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.