ArticleJournal of virology1993
Adult mouse kidneys become permissive to acute polyomavirus infection and reactivate persistent infections in response to cellular damage and regeneration.
Article in Journal of virology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 150 citations in OpenAlex.
- Native kidney BK virus nephropathy, a systematic review.Transplant infectious disease : an official journal of the Transplantation Society · 2019Pooled it
- Reversible ureteral obstruction due to polyomavirus infection after percutaneous nephrostomy catheter placement.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2011Trial
- Review
- Article
- Prolonged Prophylactic Ureteral Stent Placement and BK Polyomavirus Infection After Renal Transplantation-A Retrospective Case-control Study.European urology open science · 2025Article
- The CXCR6-CXCL16 axis mediates T cell control of polyomavirus infection in the kidney.PLoS pathogens · 2025Article
- BK polyomavirus infection: more than 50 years and still a threat to kidney transplant recipients.Frontiers in transplantation · 2024Review
- Duration of delayed graft function and its impact on graft outcomes in deceased donor kidney transplantation.BMC nephrology · 2022Article
- The impact of prophylactic ureteral stenting during kidney transplantation on postoperative surgical outcomes.Korean journal of transplantation · 2021Article
- BK Polyomavirus Evades Innate Immune Sensing by Disrupting the Mitochondrial Network and Promotes Mitophagy.iScience · 2020Article
- The Murine Polyomavirus MicroRNA Locus Is Required To Promote Viruria during the Acute Phase of Infection.Journal of virology · 2018Article
- Ureteral stent placement and immediate graft function are associated with increased risk of BK viremia in the first year after kidney transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2017Article
- Reducing persistent polyomavirus infection increases functionality of virus-specific memory CD8 T cells.Virology · 2017Article
- Outcomes of renal transplant recipients with BK virus infection and BK virus surveillance in the Auckland region from 2006 to 2012.World journal of nephrology · 2016Article
- BK Polyomavirus and the Transplanted Kidney: Immunopathology and Therapeutic Approaches.Transplantation · 2016Review
- BK polyoma virus infection and renal disease in non-renal solid organ transplantation.Clinical kidney journal · 2016Review
- A Preliminary Study Into the Significance of Intrarenal Reflux in BK Virus Nephropathy After Kidney Transplantation.Transplantation direct · 2016Article
- Evaluation of the Gastrointestinal Tract as Potential Route of Primary Polyomavirus Infection in Mice.PloS one · 2016Article
- Comparison of anti-reflux mechanism between Double-J-Stent and standart Double-J-Stent use for risk of BK nephropathy and urinary tract Infection in kidney transplantation.International journal of clinical and experimental medicine · 2015Article
- Polyomavirus-Specific Cellular Immunity: From BK-Virus-Specific Cellular Immunity to BK-Virus-Associated Nephropathy?Frontiers in immunology · 2015Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Kidneys of newborn (but not adult) mice are normally high permissive for polyomavirus (Py) infection and readily establish persistent infections. We have proposed that ongoing cellular differentiation, which occurs in newborn mice, may be necessary for a high level of in vivo Py replication (R. Rochford, J. P. Moreno, M. L. Peake, and L. P. Villarreal, J. Virol. 66:3287-3297, 1992). This cellular differentiation requirement may also be necessary for the reactivation of a persistent Py kidney infection and could provide an alternative to the accepted view that reactivation results from immunosuppression. To examine this proposal, the ability of adult BALB/c mouse kidneys to support primary acute Py infection or to reactivate previously established persistent Py infections after kidney-specific damage was investigated. Kidney damage was induced by both chemical (glycerol, cisplatin, or methotrexate) and mechanical (through renal artery clamping to produce unilateral renal ischemia) treatments. We also examined the effects of epidermal growth factor (EGF), which enhances the rate of kidney regeneration, on Py replication. Using histopathologic techniques, in situ hybridization for Py DNA, and immunofluorescence for Py VP1 production, we established that both chemical damage and damage through renal artery clamping of adult kidneys promoted high levels of primary Py replication in these normally nonpermissive cells. This damage also promoted the efficient reactivation of Py replication from persistently infected kidneys, in the absence of immunosuppression. EGF treatment significantly increased acute Py replication and also reactivation in damaged kidneys. These results support the view that ongoing cellular division and differentiation may be needed both for high levels of acute Py replication and for reactivation of persistent infections in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.