ArticleThe Journal of experimental medicine1993
Ordered rearrangement of variable region genes of the T cell receptor gamma locus correlates with transcription of the unrearranged genes.
Article in The Journal of experimental medicine, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 104 citations in OpenAlex.
- Lymphoid cell development from fetal hematopoietic progenitors and human pluripotent stem cells.Immunological reviews · 2023Review
- Variable Extent of Lineage-Specificity and Developmental Stage-Specificity of Cohesin and CCCTC-Binding Factor Binding Within the Immunoglobulin and T Cell Receptor Loci.Frontiers in immunology · 2018Article
- Neonatal immunology: responses to pathogenic microorganisms and epigenetics reveal an "immunodiverse" developmental state.Immunologic research · 2013Review
- The requirement for pre-TCR during thymic differentiation enforces a developmental pause that is essential for V-DJβ rearrangement.PloS one · 2011Article
- CCR10 is important for the development of skin-specific gammadeltaT cells by regulating their migration and location.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Differential roles of IL-2-inducible T cell kinase-mediated TCR signals in tissue-specific localization and maintenance of skin intraepithelial T cells.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- The innate immune response to uropathogenic Escherichia coli involves IL-17A in a murine model of urinary tract infection.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Recombination signal sequence-associated restriction on TCRdelta gene rearrangement affects the development of tissue-specific gammadelta T cells.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Functional analysis of histone methyltransferase g9a in B and T lymphocytes.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Gene placement and competition control T cell receptor gamma variable region gene rearrangement.The Journal of experimental medicine · 2008Article
- Interleukin 15 controls the generation of the restricted T cell receptor repertoire of gamma delta intestinal intraepithelial lymphocytes.Nature immunology · 2005Article
- The genomic arrangement of T cell receptor variable genes is a determinant of the developmental rearrangement pattern.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Localized gene-specific induction of accessibility to V(D)J recombination induced by E2A and early B cell factor in nonlymphoid cells.The Journal of experimental medicine · 2001Article
- Histone acetylation determines the developmentally regulated accessibility for T cell receptor gamma gene recombination.The Journal of experimental medicine · 2001Article
- A novel element upstream of the Vgamma2 gene in the murine T cell receptor gamma locus cooperates with the 3' enhancer to act as a locus control region.The Journal of experimental medicine · 1999Article
- High expression of a specific T-cell receptor gamma transcript in epithelial cells of the prostate.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Positive and negative regulation of V(D)J recombination by the E2A proteins.The Journal of experimental medicine · 1999Article
- Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibility.The Journal of experimental medicine · 1998Article
- Evidence that immunoglobulin VH-DJ recombination does not require germ line transcription of the recombining variable gene segment.Molecular and cellular biology · 1998Article
- Kinetics of T cell receptor beta, gamma, and delta rearrangements during adult thymic development: T cell receptor rearrangements are present in CD44(+)CD25(+) Pro-T thymocytes.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
T cell receptor V gamma genes rearrange to the J gamma 1 gene segment in a highly ordered fashion during development. We demonstrate a striking correlation between the pattern of expression of unrearranged V gamma genes and the timing of their rearrangement. Thus, the increases in V gamma 2 rearrangements, and decreases in V gamma 3 and V gamma 4 rearrangements observed during development are paralleled by increasing or decreasing levels of the corresponding unrearranged V gene transcript. We also provide evidence that both the V gamma 3 and V gamma 4 genes are accessible in mature V gamma 3+ cells, but that the V gamma 4 gene may be inaccessible in the progenitors of V gamma 3 cells. The results suggest that regulated local accessibility of the chromatin surrounding V gamma genes is responsible for ordered V gamma gene rearrangement during development.
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