ArticleImmunogenetics1993
Human Tcrb-V6.10 is a pseudogene with Alu repetitive sequences in the promoter region.
Article in Immunogenetics, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Human T-cell receptor variable gene segment families.Immunogenetics · 1995Review
- Human T-cell responses to Mycoplasma arthritidis-derived superantigen.Infection and immunity · 1994Article
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Authors and funding
4 authors.
Funding
Abstract
Tcrb-V6.10 represents an abnormal human V gene with an Alu insertion in the promoter, a point mutation of a conserved Cys at position 23, and a missing nonamer within the usually conserved recombinase signal sequence. Here it is shown that b-V6.10 is found in the genome of most individuals, is normally located in the Tcrb-V locus on chromosome 7, but is not rearranged or transcribed. Thus, it is likely that the abnormal signal sequence precludes recombination and that the Alu insertion results in a disabled promoter, indicating the functional importance of the affected regions. Tcrb-V6.10 probably evolved by duplication of an ancestral Tcrb V13-V6-V5 cassette, like other members of the large b-V6 subfamily, and more recently became inactivated into a pseudogene.
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