ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie1993
Characterization of bovine ciliary pigmented epithelial cells in monolayer culture: an ultrastructural, enzyme histochemical and immunohistochemical study.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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0 citing papers in PubMed, 4 citations in OpenAlex.
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4 authors at 2 institutions in 1 country.
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Abstract
Monolayer cultures of the pigmented epithelial (PE) cells derived from two regions of the pars plicata of bovine eyes were established and grown up to the third passage. After this passage, the cultures became senescent. During the first three passages, the PE cells lost their pigment granules but developed a distinct cellular polarity by forming junctional complexes at their apical cell portions and depositing basement membrane like material on their basal side. The junctional complexes were shown to be impermeable for horseradish peroxidase, suggesting that they contained tight junctions. Histochemically, the monolayer cells stained for carbonic anhydrase (CA) and Na+/K(+)-ATPase, enzymes involved in active fluid secretion. Staining for CA and Na+/K(+)-ATPase as well as for acid phosphatase and immunostaining for vimentin and actin of the cultured PE cells were comparable with that of PE cells in vivo. Therefore, PE monolayer cultures are considered to be a suitable model for experimental studies in vitro.
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