ArticleJournal of bacteriology1993
Calcium-induced conidiation in Penicillium cyclopium: calcium triggers cytosolic alkalinization at the hyphal tip.
Article in Journal of bacteriology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 51 citations in OpenAlex.
- pH Distribution along Growing Fungal Hyphae at Microscale.Journal of fungi (Basel, Switzerland) · 2022Article
- A Plastic Vegetative Growth Threshold Governs Reproductive Capacity in Aspergillus nidulans.Genetics · 2016Article
- Reproductive competence: a recurrent logic module in eukaryotic development.Proceedings. Biological sciences · 2013Review
- Article
- Live-Cell imaging and measurement of intracellular pH in filamentous fungi using a genetically encoded ratiometric probe.Eukaryotic cell · 2009Article
- Basic-zipper-type transcription factor FlbB controls asexual development in Aspergillus nidulans.Eukaryotic cell · 2008Article
- Conidiation in Penicillium cyclopium is induced by conidiogenone, an endogenous diterpene.Eukaryotic cell · 2002Article
- Intracellular pH in arbuscular mycorrhizal fungi. A symbiotic physiological markerPlant physiology · 1998Article
- A glucose-activated electron transfer system in the plasma membrane stimulates the H(+)-ATPase in Penicillium cyclopium.Journal of bacteriology · 1994Article
- The internal pH of the forespore compartment of Bacillus megaterium decreases by about 1 pH unit during sporulation.Journal of bacteriology · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Addition of Ca2+ (1 to 10 mM) to submerged cultures of Penicillium cyclopium induces conidiation. Ca2+ induced an increase in cytosolic pH from approximately 7.00 to > 7.60 in less than 10 min, as determined with the fluorescent pH probe fluorescein. Measurement of the H(+)-ATPase activity in total membrane fractions did not show any stable activation in vivo as a result of Ca2+ treatment. By fluorescence ratio imaging microscopy, it was observed that vegetative hyphae exhibit a tip-to-base pH gradient, with the tip being more acidic. Ca2+ caused this gradient to dissipate within 10 min. The effect of several agents that are supposed to cause internal acidification, by different means, on conidiation was tested. Concentrations of these agents that did not significantly affect growth but inhibited Ca(2+)-induced conidiation also prevented the intracellular alkalinization observed after exposure to the cation. Calcium channel blockers (lanthanum, cobalt, verapamil, and nifedipine) were not able to inhibit Ca(2+)-induced conidiation, although their effect on calcium uptake was not evaluated. However, the combined results point towards externally bound Ca2+ as the primary agent of conidiation induction, causing changes in plasma membrane function which disrupt the pH gradient observed during apical growth.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.