ArticleProceedings of the National Academy of Sciences of the United States of America1993
Suppression of tumorigenicity in simian virus 40-transformed 3T3 cells transfected with alpha-actinin cDNA.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 156 citations in OpenAlex.
- MiR-200a Regulates Nasopharyngeal Carcinoma Cell Migration and Invasion by Targeting MYH10.Journal of Cancer · 2020Article
- Actinin-4 in keratinocytes regulates motility via an effect on lamellipodia stability and matrix adhesions.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Activity-based protein profiling of host-virus interactions.Trends in biotechnology · 2012Review
- Rac-dependent doubling of HeLa cell area and impairment of cell migration and cell cycle by compounds from Iris germanica.Protoplasma · 2011Article
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- Oncogenic Ras-induced morphologic change is through MEK/ERK signaling pathway to downregulate Stat3 at a posttranslational level in NIH3T3 cells.Neoplasia (New York, N.Y.) · 2008Article
- Profilin-1 is a negative regulator of mammary carcinoma aggressiveness.British journal of cancer · 2007Article
- Cell motility and local viscoelasticity of fibroblasts.Biophysical journal · 2005Article
- Human diploid fibroblasts are resistant to MEK/ERK-mediated disruption of the actin cytoskeleton and invasiveness stimulated by Ras.Oncogene · 2005Article
- Transcriptional basis of KRAS oncogene-mediated cellular transformation in ovarian epithelial cells.Oncogene · 2004Article
- Mutant alpha-actinin-4 promotes tumorigenicity and regulates cell motility of a human lung carcinoma.Oncogene · 2004Article
- Tumor suppressor activity of profilin requires a functional actin binding site.Molecular biology of the cell · 2004Article
- EPLIN regulates actin dynamics by cross-linking and stabilizing filaments.The Journal of cell biology · 2003Article
- Inhibition of anchorage-independent growth of transformed NIH3T3 cells by epithelial protein lost in neoplasm (EPLIN) requires localization of EPLIN to actin cytoskeleton.Molecular biology of the cell · 2002Article
- Post-transcriptional down-regulation of ROCKI/Rho-kinase through an MEK-dependent pathway leads to cytoskeleton disruption in Ras-transformed fibroblasts.Molecular biology of the cell · 2002Article
- Cytoskeletal organization in tropomyosin-mediated reversion of ras-transformation: Evidence for Rho kinase pathway.Oncogene · 2001Article
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- Suppression of tumorigenicity in breast cancer cells by the microfilament protein profilin 1.The Journal of experimental medicine · 2000Article
- v-Src suppresses SHPS-1 expression via the Ras-MAP kinase pathway to promote the oncogenic growth of cells.Oncogene · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human cytoskeletal alpha-actinin cDNA was transfected into highly malignant simian virus 40-transformed BALB/c 3T3 (SVT2) cells that express 6-fold lower levels of alpha-actinin than nontransformed BALB/c 3T3 cells. SVT2 clones expressing various levels of alpha-actinin were isolated and their structure and tumorigenic properties were determined. Transfected SVT2 clones expressing alpha-actinin at levels found in nontumorigenic 3T3 cells displayed a flatter phenotype, a decreased ability to grow in suspension culture in soft agar, and a marked reduction in their ability to form tumors in syngeneic BALB/c mice and in athymic nude mice. Clones overexpressing alpha-actinin at the highest level (about 2-fold higher than 3T3 cells) were completely suppressed in their ability to form tumors in syngeneic BALB/c mice. The results suggest that alpha-actinin, an actin-crosslinking protein that is also localized in cell junctions, may have an effective suppressive ability on the transformed phenotype.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.