ArticleProceedings of the National Academy of Sciences of the United States of America1993
Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
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- Rodent Models of Experimental Endometriosis: Identifying Mechanisms of Disease and Therapeutic Targets.Current women's health reviews · 2018Review
- Prospects of IL-2 in Cancer Immunotherapy.BioMed research international · 2018Review
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- Regulation of inflammation by interleukin-4: a review of "alternatives".Journal of leukocyte biology · 2012Review
- Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation.Nature reviews. Immunology · 2005Review
- Jak3-independent trafficking of the common gamma chain receptor subunit: chaperone function of Jaks revisited.Molecular and cellular biology · 2004Article
- Interleukin-2 (IL-2) regulates the accessibility of the IL-2-responsive enhancer in the IL-2 receptor alpha gene to transcription factors.Molecular and cellular biology · 1999Article
- Functional cleavage of the common cytokine receptor gamma chain (gammac) by calpain.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Genetic mapping in the mouse of Kif4, a gene encoding a kinesin-like motor protein.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells.The Journal of experimental medicine · 1997Article
- A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- A membrane-proximal region of the interleukin-2 receptor gamma c chain sufficient for Jak kinase activation and induction of proliferation in T cells.Molecular and cellular biology · 1996Article
- Screening for mutations causing X-linked severe combined immunodeficiency in the IL-2R gamma chain gene by single-strand conformation polymorphism analysis.Human genetics · 1995Article
- Missense mutation in exon 7 of the common gamma chain gene causes a moderate form of X-linked combined immunodeficiency.The Journal of clinical investigation · 1995Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The IL-2R gamma chain (IL-2R gamma) is an essential component of high- and intermediate-affinity IL-2Rs, playing critical roles for ligand binding and internalization. Recently, our laboratory has demonstrated that IL-2R gamma mutation results in X chromosome-linked severe combined immunodeficiency in humans, suggesting that IL-2R gamma plays a vital role in thymic maturation of human T cells. We now report the isolation and characterization of cDNAs encoding murine IL-2R gamma. The open reading frame encodes 369 aa, identical in length to that encoded by the human IL-2R gamma cDNA. Murine IL-2R gamma and human IL-2R gamma have 69% and 70% identity at the nucleotide and amino acid levels, respectively. As expected, the murine IL-2R gamma retains the WSXWS motif and four cysteine residues characteristic of cytokine receptor superfamily members. IL-2R gamma mRNA distribution shows significant tissue specificity, with particularly high-level expression in spleen and thymus, and higher expression in single-positive (CD4+8- or CD4-8+)-enriched thymocytes than in double-negative (CD4-8-) thymocytes. Finally, we have localized the murine IL-2R gamma gene, Il2rg, to the X chromosome between Rsvp and Plp and demonstrated that a defect in IL-2R gamma is not responsible for the X chromosome-linked xid mutation, which maps to this same region. The cloning of the murine IL-2R gamma cDNA will facilitate the investigation of the role of this protein in lymphocyte function and thymic development.
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