ArticleNaunyn-Schmiedeberg's archives of pharmacology1993
Tolbutamide- and diazoxide-sensitive K+ channel in neurons of substantia nigra pars reticulata.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 43 citations in OpenAlex.
- Latest Insights into the Pathophysiology of Migraine: the ATP-Sensitive Potassium Channels.Current pain and headache reports · 2020Review
- Inhibitory and excitatory neuromodulation by hydrogen peroxide: translating energetics to information.The Journal of physiology · 2015Review
- Intrinsic and integrative properties of substantia nigra pars reticulata neurons.Neuroscience · 2011Review
- H2O2: a dynamic neuromodulator.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2011Review
- Regulation of Substantia Nigra Pars Reticulata GABAergic Neuron Activity by H₂O₂ via Flufenamic Acid-Sensitive Channels and KFrontiers in systems neuroscience · 2011Article
- Modulation of the excitability of cholinergic basal forebrain neurones by KATP channels.The Journal of physiology · 2004Article
- Activation of ATP-sensitive K+ (K(ATP)) channels by H2O2 underlies glutamate-dependent inhibition of striatal dopamine release.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Mice transgenically overexpressing sulfonylurea receptor 1 in forebrain resist seizure induction and excitotoxic neuron death.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Alternative sulfonylurea receptor expression defines metabolic sensitivity of K-ATP channels in dopaminergic midbrain neurons.The EMBO journal · 1999Article
- Cell-type specific expression of ATP-sensitive potassium channels in the rat hippocampus.The Journal of physiology · 1999Article
- Adenosine release mediates cyanide-induced suppression of CA1 neuronal activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Blockade of dopamine storage, but not of dopamine synthesis, prevents activation of a tolbutamide-sensitive K+ channel in the guinea-pig substantia nigra.Experimental brain research · 1996Article
- Hypoxic changes in rat locus coeruleus neurons in vitro.The Journal of physiology · 1995Article
- Metabolic inhibition and low internal ATP activate K-ATP channels in rat dopaminergic substantia nigra neurones.Pflugers Archiv : European journal of physiology · 1995Article
- Identification of an ATP-sensitive K+ channel in spiny neurons of rat caudate nucleus.Pflugers Archiv : European journal of physiology · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Single-channel K+ currents were recorded in cell-attached patches from slices of rat substantia nigra. On the somata of neurons in the caudal half of the substantia nigra pars reticulata a K+ selective channel with a unitary conductance of 71 pS (154 mmol/l K+ in pipette filling solution) was identified. The channel was activated both by application of diazoxide (300 mumol/l) and by energy-depleting conditions (200 mumol/l cyanide) and was reversibly blocked by tolbutamide (0.1-1 mmol/l). It is concluded that neurons in the substantia nigra pars reticulata of the rat contain a typical ATP-sensitive K+ channel the activity of which can be modulated by diazoxide and sulfonylureas.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.