ArticleThe Journal of experimental medicine1993
Immature surface Ig+ B cells can continue to rearrange kappa and lambda L chain gene loci.
Article in The Journal of experimental medicine, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 137 citations in OpenAlex.
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- Comparative Aspects of Immunoglobulin Gene Rearrangement Arrays in Different Species.Frontiers in immunology · 2022Review
- Murine Bone Marrow Niches from Hematopoietic Stem Cells to B Cells.International journal of molecular sciences · 2018Review
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- Circadian clock cryptochrome proteins regulate autoimmunity.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Immature Lymphocytes InhibitJournal of immunology (Baltimore, Md. : 1950) · 2017Article
- Checkpoints that control B cell development.The Journal of clinical investigation · 2015Review
- Toll-like receptor 4-mediated signaling regulates IL-7-driven proliferation and differentiation of B-cell precursors.Cellular & molecular immunology · 2014Article
- Article
- Allelic exclusion of immunoglobulin genes: models and mechanisms.Immunological reviews · 2010Review
- BCL6 is critical for the development of a diverse primary B cell repertoire.The Journal of experimental medicine · 2010Article
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- Retroviral transduction of IL-7Ralpha into IL-7Ralpha-/- bone marrow progenitors: correction of lymphoid deficiency and induction of neutrophilia.Gene therapy · 2005Article
- Bruton's tyrosine kinase cooperates with the B cell linker protein SLP-65 as a tumor suppressor in Pre-B cells.The Journal of experimental medicine · 2003Article
- Bruton's tyrosine kinase regulates the activation of gene rearrangements at the lambda light chain locus in precursor B cells in the mouse.The Journal of experimental medicine · 2001Article
- Double light chain producing lymphocytes: an enigma of allelic exclusion.Immunologic research · 2001Review
- B cell receptor expression level determines the fate of developing B lymphocytes: receptor editing versus selection.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Revising B cell receptors.The Journal of experimental medicine · 2000Review
- A dual role for Src homology 2 domain-containing inositol-5-phosphatase (SHIP) in immunity: aberrant development and enhanced function of b lymphocytes in ship -/- mice.The Journal of experimental medicine · 2000Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pro and pre B cells possess the long-term capacity to proliferate in vitro on stromal cells and interleukin 7 (IL-7) and can differentiate to surface immunoglobulin (sIg+) cells upon removal of IL-7 from the cultures. A key event in this differentiation is the extensive cell loss due to apoptosis. Because the proto-oncogene bcl-2 can promote cell survival, we established pre-B cell lines from E mu-bcl-2 transgenic mice. These pre-B cells have the same properties as those derived from non-bcl-2 transgenic mice except that they do not die by apoptosis. This allowed us to study the fate of newly formed B cells in vitro for a longer period of time. Here we show that early during the differentiation of pre-B cells, upregulation of RAG-1 and RAG-2 expression go hand in hand with rearrangements of the Ig gene loci. Moreover, the newly formed sIg+ B cells continue to express RAG-1 and RAG-2 and continue to rearrange L chain gene loci, even in the absence of proliferation, in an orderly fashion, so that kappa L+ sIg+ cells can become lambda L+ sIg+ or sIg- cells, whereas lambda L+ sIg+ cells can become sIg-, but not kappa L+ sIg+ cells. Thus, deposition of a complete Ig molecule on the surface of a B cell does not automatically stop the Ig-rearrangement machinery.
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