ArticleGenetics1993
Pattern of nucleotide substitutions in growth hormone-prolactin gene family: a paradigm for evolution by gene duplication.
Article in Genetics, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Article
- Molecular evolution of UCP1 and the evolutionary history of mammalian non-shivering thermogenesis.BMC evolutionary biology · 2009Article
- Complex signatures of locus-specific selective pressures and gene conversion on Human Growth Hormone/Chorionic Somatomammotropin genes.Human mutation · 2008Article
- Whole-gene positive selection, elevated synonymous substitution rates, duplication, and indel evolution of the chloroplast clpP1 gene.PloS one · 2008Article
- Molecular evolution of the ependymin protein family: a necessary update.BMC evolutionary biology · 2007Article
- Evolution of growth hormone in primates: the GH gene clusters of the New World monkeys marmoset (Callithrix jacchus) and white-fronted capuchin (Cebus albifrons).Journal of molecular evolution · 2006Article
- Cloning, functional identification and sequence analysis of flavonoid 3'-hydroxylase and flavonoid 3',5'-hydroxylase cDNAs reveals independent evolution of flavonoid 3',5'-hydroxylase in the Asteraceae family.Plant molecular biology · 2006Article
- Modeling the site-specific variation of selection patterns along lineages.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Gene conversion and functional divergence in the beta-globin gene family.Journal of molecular evolution · 2004Article
- A maximum likelihood method for detecting functional divergence at individual codon sites, with application to gene family evolution.Journal of molecular evolution · 2004Article
- Episodic molecular evolution of pituitary growth hormone in Cetartiodactyla.Journal of molecular evolution · 2004Article
- Article
- Likelihood analysis of the chalcone synthase genes suggests the role of positive selection in morning glories (Ipomoea).Journal of molecular evolution · 2004Article
- Exploring the evolutionary history of the alcohol dehydrogenase gene (Adh) duplication in species of the family tephritidae.Journal of molecular evolution · 2003Article
- Maximum likelihood methods for detecting adaptive evolution after gene duplication.Journal of structural and functional genomics · 2003Review
- Monosomy of a specific chromosome determines L-sorbose utilization: a novel regulatory mechanism in Candida albicans.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Substitution rate comparisons between grasses and palms: synonymous rate differences at the nuclear gene Adh parallel rate differences at the plastid gene rbcL.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- The molecular evolution of vertebrate growth hormones: a pattern of near-stasis interrupted by sustained bursts of rapid change.Journal of molecular evolution · 1996Article
- Rat mammary-gland transferrin: nucleotide sequence, phylogenetic analysis and glycan structure.The Biochemical journal · 1995Article
- Synonymous and nonsynonymous substitutions in mammalian genes and the nearly neutral theory.Journal of molecular evolution · 1995Article
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1 author.
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Abstract
The growth hormone-prolactin gene family in mammals is an interesting example of evolution by gene duplication. Divergence among members of duplicated gene families and among species was examined by using reported gene sequences of growth hormone, prolactin and their receptors. Sequence divergence among species was found to show a general tendency in which a generation-time effect is pronounced for synonymous substitutions but not so for nonsynonymous substitutions. Divergence among duplicated genes is characterized by the relatively high rate of nonsynonymous substitutions, i.e., the rate is close to that of synonymous ones. In view of the stage- and tissue-specific expression of duplicated genes, some of the amino acid substitutions among duplicated genes is likely to be caused by positive Darwinian selection.
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