ArticleGenetics1993
Mutation in the bimD gene of Aspergillus nidulans confers a conditional mitotic block and sensitivity to DNA damaging agents.
Article in Genetics, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- Cohesin cofactor dosage sets the rate of loop extrusion, rendering genome folding tunable yet vulnerable to genetic disruption.Molecular cell · 2026Article
- Dosage sensitivity of the loop extrusion rate confers tunability to genome folding while creating vulnerability to genetic disruption.bioRxiv : the preprint server for biology · 2025Article
- PDS5A and PDS5B in Cohesin Function and Human Disease.International journal of molecular sciences · 2021Review
- The nature of meiotic chromosome dynamics and recombination in budding yeast.Journal of microbiology (Seoul, Korea) · 2019Review
- The Rio1 protein kinases/ATPases: conserved regulators of growth, division, and genomic stability.Current genetics · 2019Review
- The SUMO Pathway in Mitosis.Advances in experimental medicine and biology · 2017Review
- Involvement of the Cohesin Cofactor PDS5 (SPO76) During Meiosis and DNA Repair in Arabidopsis thaliana.Frontiers in plant science · 2015Article
- The RFX protein RfxA is an essential regulator of growth and morphogenesis in Penicillium marneffei.Eukaryotic cell · 2010Article
- Pds5 is required for homologue pairing and inhibits synapsis of sister chromatids during yeast meiosis.The Journal of cell biology · 2009Article
- Recombination protein Tid1p controls resolution of cohesin-dependent linkages in meiosis in Saccharomyces cerevisiae.The Journal of cell biology · 2005Article
- Pds5p regulates the maintenance of sister chromatid cohesion and is sumoylated to promote the dissolution of cohesion.The Journal of cell biology · 2003Article
- Intra-G1 arrest in response to UV irradiation in fission yeast.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Establishment and maintenance of sister chromatid cohesion in fission yeast by a unique mechanism.The EMBO journal · 2001Article
- Evidence that replication fork components catalyze establishment of cohesion between sister chromatids.Proceedings of the National Academy of Sciences of the United States of America · 2001Review
- BimD/SPO76 is at the interface of cell cycle progression, chromosome morphogenesis, and recombination.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Characterization of vertebrate cohesin complexes and their regulation in prophase.The Journal of cell biology · 2000Article
- Pds5p is an essential chromosomal protein required for both sister chromatid cohesion and condensation in Saccharomyces cerevisiae.The Journal of cell biology · 2000Article
- Androgen-induced proliferative quiescence in prostate cancer cells: the role of AS3 as its mediator.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- An extragenic suppressor of the mitosis-defective bimD6 mutation of Aspergillus nidulans codes for a chromosome scaffold protein.Genetics · 1996Article
- myoA of Aspergillus nidulans encodes an essential myosin I required for secretion and polarized growth.The Journal of cell biology · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Mutation in the bimD gene of Aspergillus nidulans results in a mitotic block in anaphase characterized by a defective mitosis. Mutation in bimD also confers, at temperatures permissive for the mitotic arrest phenotype, an increased sensitivity to DNA damaging agents, including methyl methanesulfonate and ultraviolet light. In order to better understand the relationship between DNA damage and mitotic progression, we cloned the bimD gene from Aspergillus. A cosmid containing the bimD gene was identified among pools of cosmids by cotransformation with the nutritional selective pyrG gene of a strain carrying the recessive, temperature-sensitive lethal bimD6 mutation. The bimD gene encodes a predicted polypeptide of 166,000 daltons in mass and contains amino acid sequence motifs similar to those found in some DNA-binding transcription factors. These sequences include a basic domain followed by a leucine zipper, which together are called a bZIP motif, and a carboxyl-terminal domain enriched in acidic amino acids. Overexpression of the wild-type bimD protein resulted in an arrest of the nuclear division cycle that was reversible and determined to be in either the G1 or S phase of the cell cycle. Our data suggest that bimD may play an essential regulatory role relating to DNA metabolism which is required for a successful mitosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.