ArticleGastroenterologia Japonica1993
Effect of epidermal growth factor by different routes of administration on the small intestinal mucosa of rats fed elemental diet.
Article in Gastroenterologia Japonica, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 25 citations in OpenAlex.
- Chronic lipid hydroperoxide stress suppresses mucosal proliferation in rat intestine: potentiation of ornithine decarboxylase activity by epidermal growth factor.Digestive diseases and sciences · 2003Article
- Epidermal growth factor receptor is increased in rabbit intestinal brush border membrane after small bowel resection.Digestive diseases and sciences · 2000Article
- Trophic effects of glicentin on rat small-intestinal mucosa in vivo and in vitro.Journal of gastroenterology · 1997Article
- Article
- Epidermal growth factor enhances repair of rat intestinal mucosa damaged by oral administration of methotrexate.Journal of gastroenterology · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study was undertaken to investigate the effect of epidermal growth factor (EGF) on the rat small intestinal mucosa by three different routes of administration. Four-week-old rats were fed elemental diet for 4 weeks and were administered EGF either subcutaneously, intraluminally or intraperitoneally with mini-osmotic pumps for a week. Intraperitoneal administration of EGF resulted in a significant increase of mucosal wet weight, mucosal content of protein and DNA, villus height, crypt depth and crypt cell production rate. Intraluminal or subcutaneous administration of EGF tended to increase those morphological and proliferative parameters, but did not cause any significant change. We conclude that EGF caused the hyperplasia of the small intestine of rats maintained on oral elemental diet and that this trophic effect was clearly shown by the intraperitoneal route of administration, rather than by the intraluminal route. These results suggest that EGF receptors located in the basal portion of crypt cells play a more important role than those located in the microvillous membrane.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.