ArticleThe Biochemical journal1993
Molecular cloning and heterologous expression of an alternatively spliced human Mu class glutathione S-transferase transcript.
Article in The Biochemical journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 55 citations in OpenAlex.
- Protein alterations in women with chronic widespread pain--An explorative proteomic study of the trapezius muscle.Scientific reports · 2015Article
- Pharmacogenomics of cisplatin-induced ototoxicity.Pharmacogenomics · 2011Review
- A structural basis for cellular uptake of GST-fold proteins.PloS one · 2011Article
- Tetramerization and cooperativity in Plasmodium falciparum glutathione S-transferase are mediated by atypic loop 113-119.The Journal of biological chemistry · 2009Article
- The Anopheles gambiae glutathione transferase supergene family: annotation, phylogeny and expression profiles.BMC genomics · 2003Article
- Cancer drugs, genetic variation and the glutathione-S-transferase gene family.American journal of pharmacogenomics : genomics-related research in drug development and clinical practice · 2003Review
- Cloning and expression of a novel Mu class murine glutathione transferase isoenzyme.The Biochemical journal · 2002Article
- Proton release on binding of glutathione to alpha, Mu and Delta class glutathione transferases.The Biochemical journal · 1999Article
- The role of alternative mRNA splicing in generating heterogeneity within the Anopheles gambiae class I glutathione S-transferase family.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Identification of a novel murine glutathione S-transferase class mu gene.The Biochemical journal · 1998Article
- Purification and characterization of a recombinant human Theta-class glutathione transferase (GSTT2-2).The Biochemical journal · 1996Article
- Variability of glutathione S-transferase isoenzyme patterns in matched normal and cancer human breast tissue.The Biochemical journal · 1994Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two cDNA clones encoding a new Mu class glutathione S-transferase (GST) have been isolated from a human testis cDNA library. Both clones are incomplete and appear to result from alternative splicing. One clone is missing the sequence encoding exon 4 and the other is missing exon 8. The complete sequence of the previously undescribed isoenzyme can be deduced from the two cDNA clones. This is the first report of alternative splicing in a GST transcript and may represent either a novel form of regulation in this multigene family or illegitimate transcription and experimental alternative splicing as part of the evolutionary process. By combining components from each clone a complete cDNA has been constructed and the encoded protein expressed in Escherichia coli. In general, the recombinant enzyme has relatively low activity when compared with all the previously described human Mu class GST isoenzymes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.