ArticleBiophysical journal1993
Single event recording shows that docking onto receptor alters the kinetics of membrane fusion mediated by influenza hemagglutinin.
Article in Biophysical journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Comparison of Cell Fusions Induced by Influenza Virus and SARS-CoV-2.International journal of molecular sciences · 2022Review
- Interaction of the Amino-Terminal Domain of the ISAV Fusion Protein with a Cognate Cell Receptor.Pathogens (Basel, Switzerland) · 2020Article
- Stochastic fusion simulations and experiments suggest passive and active roles of hemagglutinin during membrane fusion.Biophysical journal · 2014Article
- Influenza virus-membrane fusion triggered by proton uncaging for single particle studies of fusion kinetics.Analytical chemistry · 2012Article
- Review
- Comprehensive kinetic analysis of influenza hemagglutinin-mediated membrane fusion: role of sialate binding.Biophysical journal · 2001Article
- Delay of influenza hemagglutinin refolding into a fusion-competent conformation by receptor binding: a hypothesis.Biophysical journal · 2000Article
- Fusion flashes illuminate kinetics.Biophysical journal · 1993Article
- Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme.Critical reviews in biochemistry and molecular biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The initial steps of membrane fusion, receptor binding and membrane destabilization, are mediated by the envelope glycoprotein hemagglutinin of influenza virus. Interaction between these functions was determined from the time course of individual virion fusions to a planar membrane with and without receptor. With receptor, fusion was described by a Poisson process. In the absence of receptor, the time course was more complicated and could not be described with exponential rate constants. The conversion of a non-Markovian process into a simple Markov chain is direct evidence that receptor binding fundamentally alters the route of fusion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.