Evidence map›Paper›PMID 8369407›Full record

ArticleBiophysical journal1993

Lateral diffusion in an archipelago. Single-particle diffusion.

M J Saxton

Open access · bronzeAbstract read
In one paragraph

Article in Biophysical journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 284 citations in OpenAlex.

  1. Article
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  4. Macromolecular interactions and geometrical confinement determine the 3D diffusion of ribosome-sized particles in liveProceedings of the National Academy of Sciences of the United States of America · 2025
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  16. Trajectories in nanotechnology: embracing complexity, seeking analogies.Drug delivery and translational research · 2021
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  19. Review
  20. Article

63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

M J SaxtonInstitute of Theoretical Dynamics, University of California, Davis 95616.
Institute of Theoretical Physics · CN

Funding

LATERAL DIFFUSION IN AN ARCHIPELAGO: MONTE CARLO STUDIESR01GM038133 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI SAXTON, MICHAEL J. · 1988 to 2011
$1.9M
NIGMS NIH HHS GM-38133
6 · The paper itself

Abstract

Several laboratories have measured lateral diffusion of single particles on the cell surface, and these measurements may reveal an otherwise inaccessible level of submicroscopic organization of cell membranes. Pitfalls in the interpretation of these experiments are analyzed. Random walks in unobstructed systems show structure that could be interpreted as free diffusion, obstructed diffusion, directed motion, or trapping in finite domains. To interpret observed trajectories correctly, one must consider not only the trajectories themselves but also the probabilities of occurrence of various trajectories. Measures of the asymmetry of obstructed and unobstructed random walks are calculated, and probabilities are evaluated for random trajectories that resemble either directed motion or diffusion in a bounded region.

Indexed as

Models, BiologicalCell MembraneDiffusionMathematicsMembrane LipidsMonte Carlo MethodProbabilityMembrane Lipids

Identifiers

PMID8369407
PMCPMC1262511
OpenAlexW2067790068

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.