ArticleProceedings of the National Academy of Sciences of the United States of America1993
Delineation of an extended surface contact area on human CD4 involved in class II major histocompatibility complex binding.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 71 citations in OpenAlex.
- Article
- Extracellular domain, hinge, and transmembrane determinants affecting surface CD4 expression of a novel anti-HIV chimeric antigen receptor (CAR) construct.bioRxiv : the preprint server for biology · 2023Article
- CD4 and LAG-3 from sharks to humans: related molecules with motifs for opposing functions.Frontiers in immunology · 2023Article
- Identification of aceNKPs, a committed common progenitor population of the ILC1 and NK cell continuum.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Immunological Targets for Immunotherapy: Inhibitory T Cell Receptors.Methods in molecular biology (Clifton, N.J.) · 2020Review
- Association of LAG3 genetic variation with an increased risk of PD in Chinese female population.Journal of neuroinflammation · 2019Article
- The γδTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness.Nature immunology · 2018Article
- LAG3 (CD223) as a cancer immunotherapy target.Immunological reviews · 2017Review
- Article
- Review
- Association of the porcine cluster of differentiation 4 gene with T lymphocyte subpopulations and its expression in immune tissues.Asian-Australasian journal of animal sciences · 2013Article
- Engineered single human CD4 domains as potent HIV-1 inhibitors and components of vaccine immunogens.Journal of virology · 2011Article
- LAG-3 in Cancer Immunotherapy.Current topics in microbiology and immunology · 2011Review
- Co-receptors and recognition of self at the immunological synapse.Current topics in microbiology and immunology · 2010Review
- Biallelic, ubiquitous transcription from the distal germline Ig{kappa} locus promoter during B cell development.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Cloning, expression, and characterization of fugu CD4, the first ectothermic animal CD4.Immunogenetics · 2004Article
- Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Characterization of the major histocompatibility complex class II binding site on LAG-3 protein.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- HLA-DR polymorphism affects the interaction with CD4.The Journal of experimental medicine · 1995Article
- Involvement of both major histocompatibility complex class II alpha and beta chains in CD4 function indicates a role for ordered oligomerization in T cell activation.The Journal of experimental medicine · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We describe a detailed mapping of the class II major histocompatibility complex (MHC) binding site using site-directed mutagenesis in conjunction with high-resolution CD4 structural data. Residues on all lateral surfaces of domain 1 and the neighboring portions of domain 2 participate in contacting class II MHC. Thus, in addition to the C'C" ridge that forms the human immunodeficiency virus type 1 gp120 binding site, apparent MHC contacts extend over the BED face of domain 1 and across the interdomain groove onto the FG loop of domain 2. Several models of the CD4/class II MHC interaction accounting for the extent of the CD4 surface involved are discussed, including the possibility that CD4 may contact more than one class II MHC molecule using different surfaces.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.