ArticleProceedings of the National Academy of Sciences of the United States of America1993
An upstream open reading frame represses expression of Lc, a member of the R/B family of maize transcriptional activators.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41 citing papers in PubMed, 85 citations in OpenAlex.
- From Structure to Function of Promoters and 5'UTRs in Maize.International journal of molecular sciences · 2026Review
- Complex regulation of the TaMyc1 gene expression in wheat grain synthesizing anthocyanin pigments.Molecular biology reports · 2018Article
- Article
- Genetic and molecular analysis of a purple sheath somaclonal mutant in japonica rice.Plant cell reports · 2011Article
- "HAIRY CANOLA"--Arabidopsis GL3 induces a dense covering of trichomes on Brassica napus seedlings.Plant molecular biology · 2006Article
- Comparative sequence analysis of the phytochrome C gene and its upstream region in allohexaploid wheat reveals new data on the evolution of its three constituent genomes.Plant molecular biology · 2005Article
- Overexpression of constitutive differential growth 1 gene, which encodes a RLCKVII-subfamily protein kinase, causes abnormal differential and elongation growth after organ differentiation in Arabidopsis.Plant physiology · 2004Article
- Multiple transcripts of a gene for a leucine-rich repeat receptor kinase from morning glory (Ipomoea nil) originate from different TATA boxes in a tissue-specific manner.Molecular genetics and genomics : MGG · 2004Article
- A conserved upstream open reading frame mediates sucrose-induced repression of translation.The Plant cell · 2004Article
- Expression of anthocyanins and proanthocyanidins after transformation of alfalfa with maize Lc.Plant physiology · 2003Article
- High-flavonol tomatoes resulting from the heterologous expression of the maize transcription factor genes LC and C1.The Plant cell · 2002Article
- A maize r1 gene is regulated post-transcriptionally by differential splicing of its leader.Plant molecular biology · 2002Article
- Four mutant alleles elucidate the role of the G2 protein in the development of C(4) and C(3) photosynthesizing maize tissues.Genetics · 2001Article
- Role of mRNA secondary structure in translational repression of the maize transcriptional activator Lc(1,2).Plant physiology · 2001Article
- The salt stress-inducible protein kinase gene, Esi47, from the salt-tolerant wheatgrass Lophopyrum elongatum is involved in plant hormone signaling.Plant physiology · 2001Article
- The rice R gene family: two distinct subfamilies containing several miniature inverted-repeat transposable elements.Plant molecular biology · 2000Article
- MDH1: an apple homeobox gene belonging to the BEL1 family.Plant molecular biology · 2000Article
- Transcript accumulation and utilization of alternate and non-consensus splice sites in rice granule-bound starch synthase are temperature-sensitive and controlled by a single-nucleotide polymorphism.Plant molecular biology · 1999Article
- Extreme structural heterogeneity among the members of a maize retrotransposon family.Genetics · 1998Article
- Inefficient reinitiation is responsible for upstream open reading frame-mediated translational repression of the maize R gene.The Plant cell · 1998Article
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2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The R/B genes of maize encode a family of basic helix-loop-helix proteins that determine where and when the anthocyanin-pigment pathway will be expressed in the plant. Previous studies showed that allelic diversity among family members reflects differences in gene expression, specifically in transcription initiation. We present evidence that the R gene Lc is under translational control. We demonstrate that the 235-nt transcript leader of Lc represses expression 25- to 30-fold in an in vivo assay. Repression is mediated by the presence in cis of a 38-codon upstream open reading frame. Furthermore, the coding capacity of the upstream open reading frame influences the magnitude of repression. It is proposed that translational control does not contribute to tissue specificity but prevents overexpression of the Lc protein. The diversity of promoter and 5' untranslated leader sequences among the R/B genes provides an opportunity to study the coevolution of transcriptional and translational mechanisms of gene regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.