ArticleNucleic acids research1993
RAD50 protein of S.cerevisiae exhibits ATP-dependent DNA binding.
Article in Nucleic acids research, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
44 citing papers in PubMed, 122 citations in OpenAlex.
- MRE11 deacetylation by SIRT2 promotes DNA binding to facilitate DNA end resection and ATM-dependent signaling.The Journal of clinical investigation · 2026Article
- Sae2 controls Mre11 endo- and exonuclease activities by different mechanisms.Nature communications · 2024Article
- Mre11-Rad50 oligomerization promotes DNA double-strand break repair.Nature communications · 2022Article
- Activation of Tel1The Journal of biological chemistry · 2019Article
- Consider the workhorse: Nonhomologous end-joining in budding yeast.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2016Review
- Sharpening the ends for repair: mechanisms and regulation of DNA resection.Acta biochimica et biophysica Sinica · 2016Review
- ATP-dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complex.The EMBO journal · 2016Article
- Requirement of POL3 and POL4 on non-homologous and microhomology-mediated end joining in rad50/xrs2 mutants of Saccharomyces cerevisiae.Mutagenesis · 2015Article
- The actin depolymerizing factor (ADF)/cofilin signaling pathway and DNA damage responses in cancer.International journal of molecular sciences · 2015Review
- Structure of the Rad50 DNA double-strand break repair protein in complex with DNA.The EMBO journal · 2014Article
- ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex.Nucleic acids research · 2012Article
- Identification of Mre11 as a target for heat radiosensitization.Radiation research · 2011Article
- Effect of rad50 mutation on illegitimate recombination in Saccharomyces cerevisiae.Molecular genetics and genomics : MGG · 2011Article
- The Mre11:Rad50 structure shows an ATP-dependent molecular clamp in DNA double-strand break repair.Cell · 2011Article
- The MRE11 complex: starting from the ends.Nature reviews. Molecular cell biology · 2011Review
- DDB2 complex-mediated ubiquitylation around DNA damage is oppositely regulated by XPC and Ku and contributes to the recruitment of XPA.Molecular and cellular biology · 2010Article
- MRN and the race to the break.Chromosoma · 2010Review
- DNA end resection: many nucleases make light work.DNA repair · 2009Review
- RAD50 and NBS1 form a stable complex functional in DNA binding and tethering.Nucleic acids research · 2009Article
- RAD50, an SMC family member with multiple roles in DNA break repair: how does ATP affect function?Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2009Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
RAD50 function of Saccharomyces cerevisiae is required during vegetative growth for recombinational repair of DNA double strand breaks, and during meiosis for initiation of meiotic recombination and formation of synaptonemal complex. RAD50 encodes a 153 kDa polypeptide which includes an amino-terminal ATP binding domain essential for function and two long heptad repeat regions. We show below that RAD50 protein purified from yeast exhibits ATP-dependent binding to double stranded DNA. Physical properties of the purified protein are also described. Models for RAD50 function in vivo are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.