Evidence map›Paper›PMID 8367294›Full record

ArticleNucleic acids research1993

Transcriptional repressor ZF5 identifies a new conserved domain in zinc finger proteins.

M Numoto, O Niwa, J Kaplan, K K Wong, K Merrell, K Kamiya, K Yanagihara, K Calame

Open access · bronzeAbstract read
In one paragraph

Article in Nucleic acids research, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 120 citations in OpenAlex.

  1. Article
  2. Article
  3. Genome-Wide Identification and Expression Analysis of theInternational journal of molecular sciences · 2024
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. The BTB-ZF transcription factors.Cell cycle (Georgetown, Tex.) · 2012
    Review
  14. Article
  15. Mouse chromosome 17 candidate modifier genes for thrombosis.Mammalian genome : official journal of the International Mammalian Genome Society · 2010
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. A genetic screen identifies a cellular regulator of adeno-associated virus.Proceedings of the National Academy of Sciences of the United States of America · 2001
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

M NumotoResearch Institute for Nuclear Medicine and Biology, Hiroshima University, Japan.
O Niwa
J Kaplan
K K Wong
K Merrell
K Kamiya
K Yanagihara
K Calame
Columbia University · USHiroshima University · JP

Funding

C-MYC ONCOGENE REGULATION IN NORMAL AND MALIGNANT CELLSR01CA038571 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CALAME, KATHRYN L. · 1985 to 1992
–
NCI NIH HHS CA 38571NIGMS NIH HHS GM07367
6 · The paper itself

Abstract

We have cloned a cDNA encoding a new murine C2H2 zinc finger protein, ZF5. The 51.3 kD protein contains five GL1-Kruppel type zinc fingers at the C-terminus. At its N-terminus, ZF5 has a 41 amino acid region which was found to be homologous to the N-termini of several other zinc finger proteins. This region defines a new motif within zinc finger proteins which we have named the Zinc finger N-terminal (ZiN) domain. ZF5 binds to two sites in the c-myc promoter and to the -50 bp site of the herpes simplex thymidine kinase promoter. ZF5 is a transcriptional repressor and its repression domain is located N-terminal to the zinc finger domains. A single 4 kb ZF5 mRNA is expressed widely.

Indexed as

DNA-Binding ProteinsAmino Acid SequenceAnimalsBase SequenceBinding, CompetitiveCell LineCloning, MolecularConserved SequenceDNAMiceMolecular Sequence DataPromoter Regions, GeneticProto-Oncogene Proteins c-mycRepressor ProteinsRNA, MessengerSequence Homology, Amino AcidDNADNA-Binding ProteinsProto-Oncogene Proteins c-mycRepressor ProteinsRNA, MessengerThymidine KinaseZfp161 protein, mouse

Identifiers

PMID8367294
PMCPMC309887
OpenAlexW2094285001

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.