ArticleNucleic acids research1993
Analysis of the rat hepatocyte nuclear factor (HNF) 1 gene promoter: synergistic activation by HNF4 and HNF1 proteins.
Article in Nucleic acids research, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 76 citations in OpenAlex.
- Insights into the Genetics and Signaling Pathways in Maturity-Onset Diabetes of the Young.International journal of molecular sciences · 2022Review
- Mettl3-mediated mRNA mNature communications · 2022Article
- Advances in targeting 'undruggable' transcription factors with small molecules.Nature reviews. Drug discovery · 2021Review
- The impact of hepatocyte nuclear factor-1α on liver malignancies and cell stemness with metabolic consequences.Stem cell research & therapy · 2019Review
- Transcription factor binding site enrichment analysis predicts drivers of altered gene expression in nonalcoholic steatohepatitis.Biochemical pharmacology · 2016Article
- Pancreatic and duodenal homeobox gene 1 (Pdx1) down-regulates hepatic transcription factor 1 alpha (HNF1α) expression during reprogramming of human hepatic cells into insulin-producing cells.American journal of translational research · 2015Article
- Regulation of neural stem cell differentiation by transcription factors HNF4-1 and MAZ-1.Molecular neurobiology · 2013Article
- Article
- The role of inflammation in cholestasis: clinical and basic aspects.Seminars in liver disease · 2010Review
- Distinct regulation of hepatic nuclear factor 1alpha by NKX6.1 in pancreatic beta cells.The Journal of biological chemistry · 2010Article
- Nuclear receptors as therapeutic targets in cholestatic liver diseases.British journal of pharmacology · 2009Review
- Structural basis of natural promoter recognition by a unique nuclear receptor, HNF4alpha. Diabetes gene product.The Journal of biological chemistry · 2008Article
- Serial changes in expression of functionally clustered genes in progression of liver fibrosis in hepatitis C patients.World journal of gastroenterology · 2008Article
- An enhancer element 6 kb upstream of the mouse HNF4alpha1 promoter is activated by glucocorticoids and liver-enriched transcription factors.Nucleic acids research · 2001Article
- Co-operative regulation of the transcription of human dihydrodiol dehydrogenase (DD)4/aldo-keto reductase (AKR)1C4 gene by hepatocyte nuclear factor (HNF)-4alpha/gamma and HNF-1alpha.The Biochemical journal · 2001Article
- SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4.The Journal of biological chemistry · 1998Article
- Liver-enriched transcription factors uncoupled from expression of hepatic functions in hepatoma cell lines.Molecular and cellular biology · 1997Article
- The HNF1/HNF4-dependent We2 element of woodchuck hepatitis virus controls viral replication and can activate the N-myc2 promoter.Journal of virology · 1996Article
- Cellular factors controlling the activity of woodchuck hepatitis virus enhancer II.Journal of virology · 1996Article
- Positive regulation of the vHNF1 promoter by the orphan receptors COUP-TF1/Ear3 and COUP-TFII/Arp1.Molecular and cellular biology · 1996Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatocyte nuclear factor (HNF) 1 is a key transcription factor involved in the expression of many liver-specific genes. We have isolated and characterized the promoter region of the rat HNF1 gene. Transfection experiments revealed that a short region between -118 and -8 is crucial for cell type-specific expression of the HNF1 gene in the hepatoma cell line, HepG2 cells. This region contains two positive cis-elements: site A, to which the transcription factor HNF4 protein can bind, and site B, to which the HNF1 protein can bind. Mutational analyses of these sites and cotransfection assays suggested that the HNF4 protein and HNF1 protein can transactivate the HNF1 gene.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.