ArticleJournal of bacteriology1993
Cloning, primary structure, and regulation of the HIS7 gene encoding a bifunctional glutamine amidotransferase: cyclase from Saccharomyces cerevisiae.
Article in Journal of bacteriology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 41 citations in OpenAlex.
- Fusion/fission protein family identification in Archaea.mSystems · 2024Article
- MIG1 as a positive regulator for the histidine biosynthesis pathway and as a global regulator in thermotolerant yeast Kluyveromyces marxianus.Scientific reports · 2019Article
- Histidine biosynthesis, its regulation and biotechnological application in Corynebacterium glutamicum.Microbial biotechnology · 2014Review
- Histidine biosynthesis.The arabidopsis book · 2011Article
- The evolution of histidine biosynthesis in archaea: insights into the his genes structure and organization in LUCA.Journal of molecular evolution · 2009Article
- Millisecond dynamics in the allosteric enzyme imidazole glycerol phosphate synthase (IGPS) from Thermotoga maritima.Journal of biomolecular NMR · 2009Article
- The role of gene fusions in the evolution of metabolic pathways: the histidine biosynthesis case.BMC evolutionary biology · 2007Article
- Nucleosome position-dependent and -independent activation of HIS7 epression in Saccharomyces cerevisiae by different transcriptional activators.Eukaryotic cell · 2003Article
- Article
- Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast.Molecular and cellular biology · 2001Article
- Subunit interactions and glutamine utilization by Escherichia coli imidazole glycerol phosphate synthase.Journal of bacteriology · 2001Article
- Histidine biosynthetic pathway and genes: structure, regulation, and evolution.Microbiological reviews · 1996Review
- Molecular evolution of the histidine biosynthetic pathway.Journal of molecular evolution · 1995Article
- Functional differences between mammalian transcription activation domains at the yeast GAL1 promoter.The EMBO journal · 1994Article
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5 authors at 2 institutions in 1 country.
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Abstract
The Saccharomyces cerevisiae HIS7 gene was cloned by its location immediately downstream of the previously isolated and characterized ARO4 gene. The two genes have the same orientation with a distance of only 416 bp between the two open reading frames. The yeast HIS7 gene represents the first isolated eukaryotic gene encoding the enzymatic activities which catalyze the fifth and sixth step in histidine biosynthesis. The open reading frame of the HIS7 gene has a length of 1,656 bp resulting in a gene product of 552 amino acids with a calculated molecular weight of 61,082. Two findings implicate a bifunctional nature of the HIS7 gene product. First, the N-terminal and C-terminal segments of the deduced HIS7 amino acid sequence show significant homology to prokaryotic monofunctional glutamine amidotransferases and cyclases, respectively, involved in histidine biosynthesis. Second, the yeast HIS7 gene is able to suppress His auxotrophy of corresponding Escherichia coli hisH and hisF mutants. HIS7 gene expression is regulated by the general control system of amino acid biosynthesis. GCN4-dependent and GCN4-independent (basal) transcription use different initiator elements in the HIS7 promoter.
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