ArticleHuman genetics1993
Absence of linkage to the ataxia telangiectasia locus in familial breast cancer.
Article in Human genetics, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 58 citations in OpenAlex.
- The Breast Cancer Tumor Suppressor TRIM29 Is Expressed via ATM-dependent Signaling in Response to Hypoxia.The Journal of biological chemistry · 2016Article
- Variation of ATM Gene Expression in Peripheral Blood Cells of Sporadic Breast Carcinomas in Iranian Patients.Avicenna journal of medical biotechnology · 2012Article
- Atm heterozygosity does not increase tumor susceptibility to ionizing radiation alone or in a p53 heterozygous background.Oncogene · 2008Article
- ATM and genome maintenance: defining its role in breast cancer susceptibility.Journal of mammary gland biology and neoplasia · 2004Review
- A high frequency of distinct ATM gene mutations in ataxia-telangiectasia.American journal of human genetics · 1996Article
- Linkage analysis and allelic imbalance in human breast cancer kindreds using microsatellite markers from the short arm of chromosome 3.Human genetics · 1995Article
- Loss of heterozygosity at chromosome 11 in breast cancer: association of prognostic factors with genetic alterations.British journal of cancer · 1995Article
- Molecular genetics of familial breast-ovarian cancer.Journal of clinical pathology · 1995Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heterozygotes for ataxia-telangiectasia (AT) are known to have an increased risk of breast cancer. The gene (or genes) responsible for almost all cases of AT has been localised to chromosome 11q by genetic linkage analysis. To examine the possibility that AT heterozygosity may account for a substantial proportion of familial breast cancer, we have typed five markers on chromosome 11q in 16 breast cancer families. We have found no evidence for linkage between breast cancer and chromosome 11q markers and conclude that the contribution of AT to familial breast cancer is likely to be minimal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.