ArticleCell and tissue research1993
Subcellular localization of immunoreactive oxytocin within thymic epithelial cells of the male mouse.
Article in Cell and tissue research, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 31 citations in OpenAlex.
- The presentation of neuroendocrine self-peptides in the thymus: an essential event for individual life and vertebrate survival.Annals of the New York Academy of Sciences · 2019Review
- The role of oxytocin in cardiovascular regulation.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014Review
- Programming of neuroendocrine self in the thymus and its defect in the development of neuroendocrine autoimmunity.Frontiers in neuroscience · 2013Review
- Focal adhesion kinases: interest in immunoendocrinology, developmental biology, and cancer.Endocrine · 2000Review
- Cryptocrine signaling in the thymus network and T cell education to neuroendocrine self-antigens.Journal of molecular medicine (Berlin, Germany) · 1995Review
- Oxytocin-producing and vasopressin-producing eosinophils in the mouse spleen: immunohistochemical, immuno-electron-microscopic and in situ hybridization studies.Cell and tissue research · 1995Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunoreactive oxytocin is expressed by thymic epithelial cells, which share properties with neuroendocrine cells. In order to investigate the assumed paracrine secretion of oxytocin, we studied the subcellular localization of immunoreactive oxytocin within thymic tissue and cultured thymic epithelial cells of the male mouse. Three types of immunoreactive cells were distinguished with the electron microscope. Immunoreactive oxytocin was found to be restricted to the cytoplasm by the use of pre- and postembedding methods. Some epithelial cells, especially in the cortex, showed a pronounced labelling of vesicular membranes and membrane tubules of the endoplasmic reticulum. In some cells, keratin filaments were associated with the electron-dense stain. Under culture conditions immunoreactive cells of different shapes were found, all displaying similar patterns of labelling. The contents of different types of vacuoles were only rarely labelled. A special class of immunoreactive exocytotic vesicles could not be identified. Thus, our results do not support neuroendocrine secretion of oxytocin via vesicles of thymic epithelial cells but offer alternative modes of secretion.
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