ArticleThe Biochemical journal1993
Sex-dependent expression and growth hormone regulation of class alpha and class mu glutathione S-transferase mRNAs in adult rat liver.
Article in The Biochemical journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 62 citations in OpenAlex.
- Transcriptomics assisted by metabolomics analysis provides insights into regulation mechanisms during carcinogenic process in a hydrodynamically transfected liver cancer model.Cancer cell international · 2025Article
- Protective effect of glutathione S-transferase enzyme activity against aflatoxin BPoultry science · 2021Article
- GSTA4 mediates reduction of cisplatin ototoxicity in female mice.Nature communications · 2019Article
- Genomics of sex hormone receptor signaling in hepatic sexual dimorphism.Molecular and cellular endocrinology · 2018Article
- Growth hormone alters the glutathione S-transferase and mitochondrial thioredoxin systems in long-living Ames dwarf mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- Effects of insulin-like growth factor 1 on glutathione S-transferases and thioredoxin in growth hormone receptor knockout mice.Age (Dordrecht, Netherlands) · 2014Article
- Effects of aging on mRNA profiles for drug-metabolizing enzymes and transporters in livers of male and female mice.Drug metabolism and disposition: the biological fate of chemicals · 2012Article
- Genotype-dependent gene expression profile of the antioxidant defense system (ADS) in the liver of a GH-transgenic zebrafish model.Transgenic research · 2011Article
- Sex differences in the expression of hepatic drug metabolizing enzymes.Molecular pharmacology · 2009Review
- Sex-different and growth hormone-regulated expression of microRNA in rat liver.BMC molecular biology · 2009Article
- Characterization of biliary conjugates of 4,4'-methylenedianiline in male versus female rats.Toxicology and applied pharmacology · 2008Article
- The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression.Pharmacology & therapeutics · 2007Review
- Article
- Growth hormone- and testosterone-dependent regulation of glutathione transferase subunit A5 in rat liver.The Biochemical journal · 1998Article
- Rat kidney glutathione S-transferase 1 subunits have C-terminal truncations.The Biochemical journal · 1996Article
- Influence of growth hormone on the hepatic mixed function oxidase and transferase systems of rainbow trout.Fish physiology and biochemistry · 1995Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sex-dependent expression and growth hormone (GH) regulation of rat liver glutathione S-transferase (GST) was examined using oligonucleotide probes that distinguish between closely related class Alpha (Ya1, Ya2, Yc) and class Mu (Yb1, Yb2, Yb3) GST mRNAs [Waxman, Sundseth, Srivastava and Lapenson (1992) Cancer Res. 52, 5797-5802]. Northern-blot analysis revealed that the steady-state levels of GST Ya1, Yb1 and Yb2 mRNAs are 2.5-3-fold higher in male as compared with female rat liver. In contrast, GST Yc and Ya2 mRNAs were expressed at a 2-3-fold higher level in female rat liver. Microsomal GST mRNA did not exhibit significant sex-dependent differences in rat liver. Treatment of male rats with GH by continuous infusion suppressed expression of the male-dominant GST Ya1, Yb1 and Yb2 mRNAs to levels at or below those found in female rat liver. This suppressive effect of GH was liver-specific, insofar as GH treatment did not alter kidney GST Ya1 mRNA levels. Hypophysectomy increased expression of the male-dominant GSTs, particularly in female rats (e.g. 8-fold elevation of GST Ya1 mRNA). GST Yc mRNA was increased approx. 2-fold in hypophysectomized males, indicating that this mRNA is subject to negative regulation by one or more pituitary-dependent factors. Continuous GH treatment of the hypophysectomized rats suppressed the expression of mRNA of GSTs Ya1, Yb1 and Yb2 when given as a continuous infusion, but not when given by an intermittent (twice daily) GH-injection schedule. Combination of continuous exposure to GH with thyroxine treatment resulted in a more complete suppression of GSTs Ya1, Yb1 and Yb2. In contrast, thyroxine increased the expression of GST Yc in hypophysectomized rats. These studies establish that several Alpha and Mu class GSTs are expressed in a sex-dependent fashion in adult rat liver, where they are regulated by multiple pituitary-dependent hormones through pretranslational mechanisms.
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