ArticleThe Biochemical journal1993
Differences in expression of transcription factor AP-1 in human promyelocytic HL-60 cells during differentiation towards macrophages versus granulocytes.
Article in The Biochemical journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 64 citations in OpenAlex.
- Imidazo[1,2-International journal of molecular sciences · 2020Article
- Article
- Prostaglandin E₂ induces oncostatin M expression in human chronic wound macrophages through Axl receptor tyrosine kinase pathway.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Deciphering the transcriptional circuitry of microRNA genes expressed during human monocytic differentiation.BMC genomics · 2009Article
- Increased c-Jun expression and reduced GATA2 expression promote aberrant monocytic differentiation induced by activating PTPN11 mutants.Molecular and cellular biology · 2009Article
- Expression and subcellular localization of syntaxin 11 in human neutrophils.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2009Article
- Lipopolysaccharide-dependent interaction between PU.1 and c-Jun determines production of lipocalin-type prostaglandin D synthase and prostaglandin D2 in macrophages.American journal of physiology. Lung cellular and molecular physiology · 2009Article
- Article
- Berberine suppresses MEK/ERK-dependent Egr-1 signaling pathway and inhibits vascular smooth muscle cell regrowth after in vitro mechanical injury.Biochemical pharmacology · 2006Article
- Cellular redox state and activating protein-1 are involved in ascorbate effect on calcitriol-induced differentiation.Protoplasma · 2001Article
- Stimulation of tissue-type plasminogen activator gene expression by sodium butyrate and trichostatin A in human endothelial cells involves histone acetylation.The Biochemical journal · 1995Article
- Modulation of poly(ADP-ribose) polymerase during neutrophilic and monocytic differentiation of promyelocytic (NB4) and myelocytic (HL-60) leukaemia cells.The Biochemical journal · 1995Article
- Cell-shape-dependent modulation of p52(PAI-1) gene expression involves a secondary response pathway.The Biochemical journal · 1995Article
- The ether lipid 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine induces expression of fos and jun proto-oncogenes and activates AP-1 transcription factor in human leukaemic cells.The Biochemical journal · 1994Article
- Dexamethasone modifies the functional responses of the granulocytic differentiating HL-60 cells.The Biochemical journal · 1994Article
- PU.1 and partners: regulation of haematopoietic stem cell fate in normal and malignant haematopoiesis.Journal of cellular and molecular medicineReview
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Commitment of HL-60 cells to macrophage or granulocytic differentiation was achieved by incubation with 4 beta-phorbol 12-myristate 13-acetate (PMA) for 30-60 min or with dimethyl sulphoxide (DMSO) for 24 h respectively. The commitment stage towards PMA-induced macrophage differentiation was associated with increases in jun B and c-fos mRNA levels, as well as with an increase in the binding activity of transcription factor AP-1. Nevertheless, gel retardation analysis indicated that the AP-1 activity detected in untreated cells was drastically reduced during the commitment stage of DMSO-induced HL-60 differentiation towards granulocytes. When HL-60 cells were treated with sodium butyrate, which induced monocytic differentiation, a remarkable increase in AP-1 binding activity was detected. Treatment of HL-60 cells with 1 alpha,25-dihydroxyvitamin D3, another monocytic differentiation agent, induced a weak, but appreciable, increase in AP-1 activity. Furthermore, addition of sodium butyrate or 1 alpha,25-dihydroxyvitamin D3 to HL-60 cells induced the expression of c-fos, c-jun, jun B and jun D proto-oncogenes. In contrast, when HL-60 cells were treated with retinoic acid, a granulocytic differentiation inducer, no enhanced AP-1 binding activity was observed, and only a weak increase in jun D mRNA level was detected. These data indicate that formation of AP-1 is not required for the induction of HL-60 differentiation towards granulocytes, whereas induction of monocytic differentiation is correlated with an increase in AP-1 activity. The differential expression of AP-1 activity may be critical in the differentiation of HL-60 cells towards monocytic or granulocytic lineages.
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